Spice1 Gene Summary [Mouse]
Predicted to be involved in metaphase chromosome alignment; mitotic spindle assembly; and regulation of centriole replication. Predicted to be located in several cellular components, including ciliary basal body; intracellular membrane-bounded organelle; and plasma membrane. Predicted to be active in centriole; centrosome; and spindle. Is expressed in adenohypophysis; brain ventricular layer; nasal cavity epithelium; testis; and thymus primordium. Orthologous to human SPICE1 (spindle and centriole associated protein 1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Spice1 |
| Official Name | spindle and centriole associated protein 1 [Source:MGI Symbol;Acc:MGI:1196252] |
| Ensembl ID | ENSMUSG00000043065 |
| Bio databases IDs | |
| Aliases | spindle and centriole associated protein 1 |
| Synonyms | CCDC52, D16Ertd480e, LOC152185, RGD1310729, SPICE, spindle and centriole associated protein 1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Spice1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Centriole duplication and mitotic chromosome congression
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- intracellular membrane-bounded organelle
- spindle apparatus
- Plasma Membrane
- basal bodies
- centrosome
- centriole
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Spice1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell division
- metaphase plate congression
- regulation of centriole replication
- spindle assembly involved in mitosis
Cellular Component
Where in the cell the gene product is active
- centrosome
- centriole
- cytoplasm
- spindle
Molecular Function
What the gene product does at the molecular level
- protein binding