Pa2g4 Gene Summary [Mouse]
Predicted to enable nucleic acid binding activity; transcription corepressor activity; and ubiquitin protein ligase binding activity. Predicted to be involved in negative regulation of apoptotic process and positive regulation of cell differentiation. Predicted to act upstream of or within negative regulation of DNA-templated transcription. Predicted to be located in cytoplasm and nucleolus. Predicted to be part of ribonucleoprotein complex. Is expressed in brain; heart; jaw; limb; and lung mesenchyme. Orthologous to human PA2G4 (proliferation-associated 2G4). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Pa2g4 |
| Official Name | proliferation-associated 2G4 [Source:MGI Symbol;Acc:MGI:894684] |
| Ensembl ID | ENSMUSG00000025364 |
| Bio databases IDs | |
| Aliases | proliferation-associated 2G4 |
| Synonyms | EBP1, HG4-1, ITAF45, p38-2G4, Plfap, proliferation-associated 2G4, Proliveration-associated protein 1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Pa2g4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ubiquitin protein ligase binding
- transcription regulator
- PKC phosphorylation site
- nucleic acid binding
- transcription co-repressor
- protein binding
- dsRNA-binding domain
- APP_MetAP
Pathways
Biological processes and signaling networks where the Pa2g4 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- Bladder Cancer Signaling
- Cell Cycle: G1/S Checkpoint Regulation
- Chronic Myeloid Leukemia Signaling
- Cyclins and Cell Cycle Regulation
- Glioma Signaling
- Molecular Mechanisms of Cancer
- Non-Small Cell Lung Cancer Signaling
- Ovarian Cancer Signaling
- Pancreatic Adenocarcinoma Signaling
- Prostate Cancer Signaling
- Small Cell Lung Cancer Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- glioblastoma
- glioblastoma cancer
- acute myeloid leukemia
- bleeding
- glioma
- glioma formation
- gastric carcinoma
- gastric epithelial cancer
role in cell
- cell death
- transcription in
- migration
- expression in
- phosphorylation in
- synthesis in
- apoptosis
- proliferation
- clonogenicity
- invasion by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- azurophil granule lumen
- Cytoplasm
- Extracellular Space
- ribosome
- nucleoplasm
- nucleoli
- nuclear envelope
- cytoplasmic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Pa2g4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of translation
- negative regulation of transcription, DNA-dependent
- negative regulation of apoptotic process
- positive regulation of cell differentiation
- rRNA processing
Cellular Component
Where in the cell the gene product is active
- nucleus
- extracellular vesicular exosome
- cytoplasm
- membrane
- nucleolus
- extracellular region
- azurophil granule lumen
Molecular Function
What the gene product does at the molecular level
- nucleic acid binding
- protein binding
- RNA binding
- ubiquitin protein ligase binding
- transcription corepressor activity