Elob Gene Summary [Mouse]
Predicted to enable transcription coactivator activity; transcription corepressor binding activity; and ubiquitin protein ligase binding activity. Predicted to be involved in target-directed miRNA degradation and transcription initiation at RNA polymerase II promoter. Part of Cul5-RING ubiquitin ligase complex and elongin complex. Is expressed in brain; brown fat; dorsal root ganglion; genitourinary system; and limb. Orthologous to human ELOB (elongin B). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Elob |
| Official Name | elongin B [Source:MGI Symbol;Acc:MGI:1914923] |
| Ensembl ID | ENSMUSG00000055839 |
| Bio databases IDs | |
| Aliases | elongin B |
| Synonyms | 0610040H15Rik, Elongin-B, RNA POLYMERASE II TRANSCRIPTION FACTOR SIII P18, SIII, SIII p18, T25547, TCEB2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Elob often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ubiquitin protein ligase binding
- transcription regulator
- transcription co-activator
- binding protein
- Ubl1_cv_Nsp3_N-like
- Ubiquitin homologues
- transcription factor binding
- protein binding
Pathways
Biological processes and signaling networks where the Elob gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- severe acute respiratory syndrome
role in cell
- proliferation
- survival
- degradation in
- killing
- killing by
- ubiquitination in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- interchromatin granule cluster fractions
- nuclear fraction
- Golgi Apparatus
- cytosol
- nucleoplasm
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Elob gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- macromolecular complex assembly
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process
- transcription initiation from RNA polymerase II promoter
- transcription elongation from RNA polymerase II promoter
- protein ubiquitination
Cellular Component
Where in the cell the gene product is active
- VCB complex
- cytosol
- Cul2-RING ubiquitin ligase complex
- elongin complex
- Cul5-RING ubiquitin ligase complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- transcription corepressor binding
- ubiquitin protein ligase binding
- protein binding