Lor Gene Summary [Mouse]
A structural constituent of cytoskeleton and structural constituent of skin epidermis. Predicted to be involved in keratinocyte differentiation and peptide cross-linking. Located in cytoplasmic side of plasma membrane. Is active in cornified envelope. Is expressed in several structures, including alimentary system; male reproductive system; sensory organ; skin; and thymus. Orthologous to human LORICRIN (loricrin cornified envelope precursor protein). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Lor |
| Official Name | loricrin [Source:MGI Symbol;Acc:MGI:96816] |
| Ensembl ID | ENSMUSG00000043165 |
| Bio databases IDs | |
| Aliases | loricrin |
| Synonyms | LOR, loricrin cornified envelope precursor protein, RGD1559993 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Lor often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- structural constituent of cytoskeleton
- Major keratinocyte cell envelope protein
- structural constituent of epidermis
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- psoriasis
- Netherton syndrome
- plaque psoriasis
- breast cancer
- loricrin keratoderma
- erythroderma
- atopic dermatitis
- erythrokeratodermia variabilis
- dermatological disorder
- oral submucous fibrosis
role in cell
- phosphorylation in
- binding in
- differentiation
- growth
- production
- maturation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cornified envelope
- cell periphery
- cellular membrane
- Nucleus
- granules
- cytosol
- cytoplasmic face of plasma membrane
- nucleoplasm
- loricrin granules
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Lor gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- keratinocyte differentiation
- cytoskeleton organization
- keratinization
- peptide cross-linking
Cellular Component
Where in the cell the gene product is active
- cornified envelope
- cytoplasm
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- structural constituent of epidermis
- protein binding
- structural constituent of cytoskeleton