Fbxl7 Gene Summary [Mouse]
Involved in G2/M transition of mitotic cell cycle; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; and protein polyubiquitination. Located in centrosome. Part of SCF ubiquitin ligase complex. Orthologous to human FBXL7 (F-box and leucine rich repeat protein 7). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Fbxl7 |
| Official Name | F-box and leucine-rich repeat protein 7 [Source:MGI Symbol;Acc:MGI:3052506] |
| Ensembl ID | ENSMUSG00000043556 |
| Bio databases IDs | |
| Aliases | F-box and leucine-rich repeat protein 7 |
| Synonyms | D230018M15RIK, FBL6, FBL7, F-box and leucine-rich repeat protein 7 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Fbxl7 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- F-box domain
- protein phosphatase 1 regulatory subunit 42
- F-box domain superfamily
- Leucine-rich repeat - CC (cysteine-containing) subfamily
- F-box-like
- enzyme
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- metastasis
- lung adenocarcinoma
- lung adenocarcinoma formation
- Alzheimer disease
- asthma
- rheumatoid arthritis
- rotator cuff injury
- lung squamous cell carcinoma
- squamous cell lung cancer
- side effect
role in cell
- invasion by
- migration
- cell viability
- function
- damage
- damage in
- ubiquitination in
- metabolism in
- function in
- degradation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- centrosome
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Fbxl7 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell division
- G2/M transition of mitotic cell cycle
- protein polyubiquitination
- SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
- mitotic cell cycle
- ubiquitin-dependent protein catabolic process
- protein ubiquitination
Cellular Component
Where in the cell the gene product is active
- centrosome
- ubiquitin ligase complex
- cytosol
- SCF ubiquitin ligase complex
Molecular Function
What the gene product does at the molecular level
- protein binding