FBXL7 Gene Summary [Human]
This gene encodes a member of the F-box protein family which is characterized by a 42-48 amino acid motif, the F-box, which binds to the S-phase kinase-associated protein 1 (Skp1) protein. The F-box proteins constitute one of the four subunits of E3 ubiquitin protein ligases called SCFs (SKP1-Cul1-F-box), which play a role in phosphorylation-dependent ubiquitination of proteins. The F-box proteins are divided into 3 subfamilies based on the other domain in the protein: F-box proteins that also have a WD-40 domain (Fbws subfamily), F-box proteins that also have leucine-rich repeats (Fbls subfamily) and F-box proteins that contain other motifs or lack known protein-interaction domains (Fbxs subfamily). The protein encoded by this gene belongs to the Fbls subfamily. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, May 2013]
Details
| Type | Protein Coding |
| Official Symbol | FBXL7 |
| Official Name | F-box and leucine rich repeat protein 7 [Source:HGNC Symbol;Acc:HGNC:13604] |
| Ensembl ID | ENSG00000183580 |
| Bio databases IDs | |
| Aliases | F-box and leucine rich repeat protein 7 |
| Synonyms | D230018M15RIK, FBL6, FBL7, F-box and leucine-rich repeat protein 7 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human FBXL7 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- F-box domain
- protein phosphatase 1 regulatory subunit 42
- F-box domain superfamily
- Leucine-rich repeat - CC (cysteine-containing) subfamily
- F-box-like
- enzyme
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- metastasis
- lung adenocarcinoma
- lung adenocarcinoma formation
- Alzheimer disease
- asthma
- rheumatoid arthritis
- rotator cuff injury
- lung squamous cell carcinoma
- squamous cell lung cancer
- side effect
role in cell
- invasion by
- migration
- cell viability
- function
- damage
- damage in
- ubiquitination in
- metabolism in
- function in
- degradation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- centrosome
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human FBXL7 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell division
- G2/M transition of mitotic cell cycle
- protein polyubiquitination
- SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
- mitotic cell cycle
- ubiquitin-dependent protein catabolic process
- protein ubiquitination
Cellular Component
Where in the cell the gene product is active
- centrosome
- ubiquitin ligase complex
- cytosol
- SCF ubiquitin ligase complex
Molecular Function
What the gene product does at the molecular level
- protein binding