Zbtb7c Gene Summary [Mouse]
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within positive regulation of fat cell differentiation and positive regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in central nervous system; craniocervical region bone; esophagus; maturing glomerular tuft; and nose. Orthologous to human ZBTB7C (zinc finger and BTB domain containing 7C). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Zbtb7c |
| Official Name | zinc finger and BTB domain containing 7C [Source:MGI Symbol;Acc:MGI:2443302] |
| Ensembl ID | ENSMUSG00000044646 |
| Bio databases IDs | |
| Aliases | zinc finger and BTB domain containing 7C |
| Synonyms | APM-1, B230208J24Rik, KR-POK, LOC108348303, ZBTB36, zinc finger and BTB domain containing 7C, ZNF857C |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Zbtb7c often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Zinc finger, C2H2 type
- zinc finger
- transcription regulator
- Broad-Complex, Tramtrack and Bric a brac
- BTB_POZ
- Zinc-finger double domain
- BTB/POZ domain
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- central nervous system cancer
- renal cancer
- familial colorectal cancer
- inguinal hernia
- metabolic syndrome X
- systemic juvenile idiopathic arthritis
- herpes zoster
role in cell
- proliferation
- differentiation
- binding in
- transcription in
- recruitment in
- deacetylation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Zbtb7c gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of cell proliferation
- positive regulation of fat cell differentiation
- positive regulation of transcription from RNA polymerase II promoter
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
Molecular Function
What the gene product does at the molecular level
- metal ion binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity