Hdac3 Gene Summary [Mouse]
Enables chromatin DNA binding activity; histone deacetylase activity; and histone decrotonylase activity. Involved in several processes, including cornified envelope assembly; establishment of skin barrier; and regulation of macromolecule metabolic process. Acts upstream of or within several processes, including negative regulation of cardiac muscle cell differentiation; regulation of DNA-templated transcription; and regulation of mitotic cell cycle. Located in cytoplasm and nucleus. Is active in chromatin. Is expressed in several structures, including alimentary system; brain; early conceptus; embryo mesenchyme; and sensory organ. Used to study endometriosis. Human ortholog(s) of this gene implicated in lung non-small cell carcinoma. Orthologous to human HDAC3 (histone deacetylase 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Retained Intron |
| Official Symbol | Hdac3 |
| Official Name | histone deacetylase 3 [Source:MGI Symbol;Acc:MGI:1343091] |
| Ensembl ID | ENSMUSG00000024454 |
| Bio databases IDs | |
| Aliases | histone deacetylase 3 |
| Synonyms | HD3, histone deacetylase 3, KDAC3, RPD3, RPD3-2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Hdac3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- nuclear export signal
- protease binding
- catalytic domain
- oligomerization domain
- NF-kappaB binding
- transcription co-repressor
- deacetylase motif
- enzyme binding
- transcription factor binding
- histone deacetylase binding
- chromatin binding
- enzyme
- deacetylase
- protein binding
- unique protein domain
- DNA binding
- Arginase-like and histone-like hydrolases
- cyclin binding
- protein deacetylase activity
- linear amide carbon-nitrogen bond hydrolase
- histone deacetylase
Pathways
Biological processes and signaling networks where the Hdac3 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- Adipogenesis pathway
- Bladder Cancer Signaling
- Calcium Signaling
- Chronic Myeloid Leukemia Signaling
- Cyclins and Cell Cycle Regulation
- Estrogen Receptor Signaling
- Glioma Signaling
- Hereditary Breast Cancer Signaling
- Huntington's Disease Signaling
- IL-12 Signaling and Production in Macrophages
- Molecular Mechanisms of Cancer
- Non-Small Cell Lung Cancer Signaling
- Osteoarthritis Pathway
- Ovarian Cancer Signaling
- Pancreatic Adenocarcinoma Signaling
- Prostate Cancer Signaling
- Role of NFAT in Cardiac Hypertrophy
- Small Cell Lung Cancer Signaling
- Telomerase Signaling
- TR/RXR Activation
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- peripheral T-cell lymphoma
- enteropathy-associated T-cell lymphoma
- angioimmunoblastic T-cell lymphoma
- acute lymphoblastic lymphoma
- lymphoma
- epithelial cancer
- epithelial neoplasia
- cancer
- neoplasia
- hepatocellular carcinoma
role in cell
- expression in
- differentiation
- apoptosis
- assembly
- cell viability
- proliferation
- survival
- activation in
- binding in
- cell death
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- Cytoplasm
- Plasma Membrane
- Golgi Apparatus
- cytosol
- nuclear foci
- nucleoplasm
- nucleoli
- spindle pole
- nuclear speckles
- polar microtubule
- central spindle
- mitotic spindle
- chromatin
- replication fork
- cytoplasmic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Hdac3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of multicellular organism growth
- transcription from RNA polymerase II promoter
- regulation of circadian rhythm
- positive regulation of transcription from RNA polymerase II promoter
- chromatin organization
- establishment of skin barrier
- negative regulation of transcription from RNA polymerase II promoter
- spindle assembly
- circadian regulation of gene expression
- negative regulation of transcription, DNA-dependent
- in utero embryonic development
- cellular response to fluid shear stress
- positive regulation of protein ubiquitination
- negative regulation of myotube differentiation
- positive regulation of TOR signaling cascade
- positive regulation of protein import into nucleus
- protein deacetylation
- negative regulation of JNK cascade
- regulation of gene expression, epigenetic
- regulation of mitotic cell cycle
- establishment of mitotic spindle orientation
- regulation of protein stability
- negative regulation of apoptotic process
- negative regulation of cardiac muscle cell differentiation
- positive regulation of protein phosphorylation
Cellular Component
Where in the cell the gene product is active
- nucleus
- mitotic spindle
- cytoplasm
- transcriptional repressor complex
- cytosol
- histone deacetylase complex
- Golgi apparatus
- plasma membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- NF-kappaB binding
- transcription corepressor binding
- chromatin DNA binding
- protein binding
- histone deacetylase binding
- histone deacetylase activity
- transcription corepressor activity
- cyclin binding
- chromatin binding
- protein deacetylase activity
- enzyme binding