Pwwp2a Gene Summary [Mouse]
Predicted to enable NuRD complex binding activity; chromatin binding activity; and methylated histone binding activity. Involved in chromatin remodeling; positive regulation of transcription elongation by RNA polymerase II; and regulation of transcriptional start site selection at RNA polymerase II promoter. Predicted to be active in nucleus. Orthologous to human PWWP2A (PWWP domain containing 2A). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Pwwp2a |
| Official Name | PWWP domain containing 2A [Source:MGI Symbol;Acc:MGI:1918052] |
| Ensembl ID | ENSMUSG00000044950 |
| Bio databases IDs | |
| Aliases | PWWP domain containing 2A |
| Synonyms | 4631424J17Rik, AK039984, D930040F23Rik, KIAA1935, LOC683932, MST101, PWWP domain containing 2A, RGD1305891 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Pwwp2a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- histone binding
- binding protein
- protein binding activity, bridging
- PWWP domain
- PWWP (Pro-Trp-Trp-Pro) domain
- chromatin binding
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Pwwp2a gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of transcription elongation from RNA polymerase II promoter
- regulation of transcriptional start site selection at RNA polymerase II promoter
- chromatin remodeling
Cellular Component
Where in the cell the gene product is active
- nucleus
Molecular Function
What the gene product does at the molecular level
- protein binding
- histone binding
- methylated histone residue binding
- chromatin binding