Hjurp Gene Summary [Mouse]
Predicted to enable histone binding activity and identical protein binding activity. Predicted to be involved in CENP-A containing chromatin assembly; chromosome segregation; and regulation of protein-containing complex assembly. Located in chromosome, centromeric region. Is expressed in several structures, including blastocyst; brain; early embryo; extraembryonic component; and neural retina. Orthologous to human HJURP (Holliday junction recognition protein). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Hjurp |
| Official Name | Holliday junction recognition protein [Source:MGI Symbol;Acc:MGI:2685821] |
| Ensembl ID | ENSMUSG00000044783 |
| Bio databases IDs | |
| Aliases | Holliday junction recognition protein |
| Synonyms | 6430706D22Rik, A730008H23Rik, C330011F01Rik, FAKTS, Gm975, hFLEG1, Holliday junction recognition protein, LOC100038822, Mfleg1, RGD1305846, URLC9 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Hjurp often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- histone binding
- Holliday junction regulator protein family C-terminal repeat
- protein binding
- Holliday junction recognition protein-associated repeat
- identical protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- prostate cancer
- migraines
- epithelial cancer
- headache
- HER2 negative hormone receptor negative breast cancer
- Parkinson disease
- lung adenocarcinoma
- lung adenocarcinoma formation
- organismal death
- colorectal cancer
role in cell
- apoptosis
- expression in
- proliferation
- degradation in
- cell viability
- growth
- quantity
- senescence
- invasion by
- fusion
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- cytosol
- nuclear foci
- prenucleolar bodies
- nucleoplasm
- nucleoli
- kinetochores
- centromeres
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Hjurp gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of DNA binding
- chromosome segregation
- regulation of protein complex assembly
- CenH3-containing nucleosome assembly at centromere
Cellular Component
Where in the cell the gene product is active
- cytosol
- kinetochore
- nucleolus
- chromosome, centromeric region
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA binding
- identical protein binding
- protein binding
- histone binding