Mybl2 Gene Summary [Mouse]
Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within cellular response to leukemia inhibitory factor and mitotic spindle assembly. Located in nucleus. Part of Myb complex. Is expressed in several structures, including brain; early conceptus; genitourinary system; hemolymphoid system; and skin. Used to study acute myeloid leukemia and myelodysplastic syndrome. Orthologous to human MYBL2 (MYB proto-oncogene like 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Mybl2 |
| Official Name | myeloblastosis oncogene-like 2 [Source:MGI Symbol;Acc:MGI:101785] |
| Ensembl ID | ENSMUSG00000017861 |
| Bio databases IDs | |
| Aliases | myeloblastosis oncogene-like 2 |
| Synonyms | B-MYB, MYBB, MYB proto-oncogene like 2, MYB-Related Protein B, myeloblastosis oncogene-like 2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Mybl2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SANT
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- transcription regulator
- SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
- regulatory domain
- DNA binding domain
- nucleic acid binding
- negative regulatory domain
- transcription activation domain
- protein binding
- sequence-specific DNA binding
- C-myb, C-terminal
- acidic domain
- Myb repeat
- phosphorylation site
- conserved domain
- double-stranded DNA binding
- Myb-like DNA-binding domain
- GT1, myb-like, SANT family
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- non-insulin-dependent diabetes mellitus
- epithelial cancer
- cancer
- liver cancer
- hepatocellular carcinoma
- prostate cancer
- metastasis
- colorectal cancer
- renal clear cell adenocarcinoma
role in cell
- activation in
- migration
- expression in
- apoptosis
- production in
- phosphorylation in
- proliferation
- survival
- adhesion
- cell cycle progression
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- cytosol
- nucleoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Mybl2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of transcription from RNA polymerase II promoter
- positive regulation of neuron apoptotic process
- mitotic cell cycle
- spindle assembly involved in mitosis
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytosol
- Myb complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
- sequence-specific DNA binding RNA polymerase II transcription factor activity