Acer1 Gene Summary [Mouse]
Enables N-acylsphingosine amidohydrolase activity. Involved in sebaceous gland development and sphingosine biosynthetic process. Acts upstream of or within ceramide catabolic process and regulation of lipid metabolic process. Located in endoplasmic reticulum. Orthologous to human ACER1 (alkaline ceramidase 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Acer1 |
| Official Name | alkaline ceramidase 1 [Source:MGI Symbol;Acc:MGI:2181962] |
| Ensembl ID | ENSMUSG00000045019 |
| Bio databases IDs | |
| Aliases | alkaline ceramidase 1 |
| Synonyms | 2310024P18Rik, Alkaline ceramidase-1, ALKCDase1, ASAH3, Cer1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Acer1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- enzyme
- protein binding
- ceramidase
Pathways
Biological processes and signaling networks where the Acer1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
regulates
- lipid
- D-erythro-dihydrosphingosine
- dihydroceramide
- ceramide
- D-sphingosine
- D-erythro-C12-NBD-ceramide
- sphingolipid
- D-erythro-C16-ceramide
- sphingosine-1-phosphate
- 2-(N-myristoylamino)-1-phenyl-1-propanol
disease
- androgenic alopecia
phenotypes
- abnormal hair growth
- abnormal retina morphology
- decreased bone mineral content
- decreased bone mineral density
- decreased circulating HDL cholesterol level
- decreased circulating cholesterol level
- decreased circulating glucose level
- abnormal awl hair morphology
- abnormal ceramide level
- abnormal coat/ hair morphology
- abnormal enzyme/coenzyme activity
- abnormal epidermis stratum corneum morphology
- abnormal epidermis stratum granulosum morphology
- abnormal hair cuticle
- abnormal hair cycle
- abnormal hair cycle anagen phase
- abnormal hair cycle telogen phase
- abnormal hair follicle bulge morphology
- abnormal hair follicle development
- abnormal hair follicle infundibulum morphology
- abnormal hair follicle morphology
- abnormal hair follicle physiology
- abnormal hair shaft morphology
- abnormal keratohyalin granule morphology
- abnormal lipid level
- abnormal piliary canal morphology
- abnormal sebaceous lipid secretion
- abnormal sebocyte morphology
- abnormal skin development
- abnormal skin physiology
- abnormal skin sebaceous gland morphology
- abnormal sphingomyelin level
- abnormal zigzag hair morphology
- alopecia
- decreased body weight
- decreased brown adipose tissue mass
- decreased brown fat cell lipid droplet size
- decreased epididymal fat pad weight
- decreased inguinal fat pad weight
- decreased sphingosine level
- delayed skin barrier formation
- dilated hair follicle infundibulum
- dry skin
- enlarged sebaceous gland
- epidermal hyperplasia
- hyperactivity
- hyperkeratosis
- impaired skin barrier function
- increased apoptosis
- increased basal metabolism
- increased energy expenditure
- increased eosinophil cell number
- increased epididymal fat pad weight
- increased food intake
- increased keratinocyte proliferation
- scaly skin
- sebaceous gland hypertrophy
- skin inflammation
- thick dermal layer
- weight loss
role in cell
- expression in
- differentiation
- response by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Endoplasmic Reticulum
- endoplasmic reticulum membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Acer1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- epidermis development
- sphingosine biosynthetic process
- sebaceous gland development
- ceramide catabolic process
- sphingolipid metabolic process
- keratinocyte differentiation
- cellular response to calcium ion
- cell differentiation
- response to alkalinity
- regulation of lipid metabolic process
- sphingolipid catabolic process
- sphingolipid biosynthetic process
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- endoplasmic reticulum
Molecular Function
What the gene product does at the molecular level
- protein binding
- ceramidase activity
- metal ion binding
- dihydroceramidase activity