Acer1 Gene Summary [Rat]
Predicted to enable N-acylsphingosine amidohydrolase activity. Predicted to be involved in several processes, including keratinocyte differentiation; response to alkaline pH; and sphingolipid metabolic process. Predicted to act upstream of or within regulation of lipid metabolic process and sphingolipid metabolic process. Predicted to be located in membrane. Predicted to be active in endoplasmic reticulum. Orthologous to human ACER1 (alkaline ceramidase 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Acer1 |
| Official Name | alkaline ceramidase 1 [Source:RGD Symbol;Acc:1588582] |
| Ensembl ID | ENSRNOG00000047368 |
| Bio databases IDs | |
| Aliases | alkaline ceramidase 1 |
| Synonyms | 2310024P18Rik, Alkaline ceramidase-1, ALKCDase1, ASAH3, Cer1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Acer1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- enzyme
- protein binding
- ceramidase
Pathways
Biological processes and signaling networks where the Acer1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- androgenic alopecia
regulates
- lipid
- D-erythro-dihydrosphingosine
- dihydroceramide
- ceramide
- D-sphingosine
- D-erythro-C12-NBD-ceramide
- sphingolipid
- D-erythro-C16-ceramide
- sphingosine-1-phosphate
- 2-(N-myristoylamino)-1-phenyl-1-propanol
role in cell
- expression in
- differentiation
- response by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Endoplasmic Reticulum
- endoplasmic reticulum membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Acer1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- epidermis development
- sphingosine biosynthetic process
- sebaceous gland development
- ceramide catabolic process
- sphingolipid metabolic process
- keratinocyte differentiation
- cellular response to calcium ion
- cell differentiation
- response to alkalinity
- regulation of lipid metabolic process
- sphingolipid catabolic process
- sphingolipid biosynthetic process
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- endoplasmic reticulum
Molecular Function
What the gene product does at the molecular level
- protein binding
- ceramidase activity
- metal ion binding
- dihydroceramidase activity