Tifa Gene Summary [Mouse]
Involved in positive regulation of canonical NF-kappaB signal transduction and tumor necrosis factor-mediated signaling pathway. Predicted to be active in cytoplasm. Is expressed in several structures, including brain ventricular layer; cerebral cortex subventricular zone; gut; liver; and trigeminal ganglion. Orthologous to human TIFA (TRAF interacting protein with forkhead associated domain). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tifa |
| Official Name | TRAF-interacting protein with forkhead-associated domain [Source:MGI Symbol;Acc:MGI:2182965] |
| Ensembl ID | ENSMUSG00000046688 |
| Bio databases IDs | |
| Aliases | TRAF-interacting protein with forkhead-associated domain |
| Synonyms | Ab2-389, T2BP, T6BP, TIFAA, Traf2 binding, TRAF6-BP, TRAF-interacting protein with forkhead-associated domain |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Tifa often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- TRAF6 binding domain
- protein binding
- forkhead associated (FHA) domain superfamily
Pathways
Biological processes and signaling networks where the Tifa gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- organismal death
- acute myeloid leukemia
- carcinoma in situ
- epithelial cancer in situ
role in cell
- expression in
- phosphorylation in
- proliferation
- activation in
- growth
- cytarabine sensitivity
- etoposide sensitivity
- etoposide resistance
- idarubicin sensitivity
- cytarabine resistance
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Tifa gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cytoplasmic pattern recognition receptor signaling pathway
- tumor necrosis factor-mediated signaling pathway
- innate immune response
- positive regulation of I-kappaB kinase/NF-kappaB cascade
- protein homooligomerization
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- cytosol
Molecular Function
What the gene product does at the molecular level
- protein binding