Bex3 Gene Summary [Mouse]
Enables death receptor binding activity and molecular function inhibitor activity. Involved in negative regulation of protein ubiquitination. Acts upstream of or within extrinsic apoptotic signaling pathway via death domain receptors. Located in cytosol. Is expressed in several structures, including genitourinary system; gut; liver; nervous system; and sensory organ. Orthologous to human BEX3 (brain expressed X-linked 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Bex3 |
| Official Name | brain expressed X-linked 3 [Source:MGI Symbol;Acc:MGI:1338016] |
| Ensembl ID | ENSMUSG00000046432 |
| Bio databases IDs | |
| Aliases | brain expressed X-linked 3 |
| Synonyms | Bex, brain expressed X-linked 3, DXS6984E, DXWsu67e, GCAP27, Hero20, HGR74, NADE, NGFRAP1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Bex3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- nerve growth factor receptor binding
- Brain expressed X-linked like family
- death receptor binding
- nuclear export signal
- protein binding
- caspase activator
- identical protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Rett syndrome
role in cell
- survival
- apoptosis
- activation in
- cell death
- growth
- differentiation
- action in
- elongation
- signaling in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- cytosol
- chromatin
- cytoplasmic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Bex3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- signal transduction
- negative regulation of protein ubiquitination
- induction of apoptosis via death domain receptors
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- cytosol
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- metal ion binding
- nerve growth factor receptor binding
- receptor binding
- cysteine-type endopeptidase activator activity involved in apoptotic process