Slc39a3 Gene Summary [Mouse]
Enables zinc ion transmembrane transporter activity. Involved in zinc ion transmembrane transport. Acts upstream of or within several processes, including T cell homeostasis; chordate embryonic development; and zinc ion transport. Located in apical plasma membrane and hippocampal mossy fiber to CA3 synapse. Is expressed in several structures, including genitourinary system; gut; nervous system; sensory organ; and yolk sac. Orthologous to human SLC39A3 (solute carrier family 39 member 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Slc39a3 |
| Official Name | solute carrier family 39 (zinc transporter), member 3 [Source:MGI Symbol;Acc:MGI:2147269] |
| Ensembl ID | ENSMUSG00000046822 |
| Bio databases IDs | |
| Aliases | solute carrier family 39 (zinc transporter), member 3 |
| Synonyms | solute carrier family 39 member 3, solute carrier family 39 (zinc transporter), member 3, ZIP-3 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Slc39a3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ZIP Zinc transporter
- protein binding
- zinc ion transporter
- transporter
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- perinuclear region
- granules
- apical membrane
- synapse
- perikaryon
- axons
- dendrites
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Slc39a3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- limb development
- in utero embryonic development
- cell morphogenesis
- embryonic cranial skeleton morphogenesis
- zinc ion transmembrane transport
- T cell homeostasis
Cellular Component
Where in the cell the gene product is active
- plasma membrane
- apical plasma membrane
Molecular Function
What the gene product does at the molecular level
- zinc ion transmembrane transporter activity