Rreb1 Gene Summary [Mouse]
Enables DNA-binding transcription factor activity. Involved in negative regulation of transcription by RNA polymerase II and positive regulation of brown fat cell differentiation. Acts upstream of or within negative regulation of DNA-templated transcription. Predicted to be located in fibrillar center and nuclear speck. Predicted to be active in nucleus. Is expressed in alimentary system; central nervous system; and genitourinary system. Used to study RASopathy. Orthologous to human RREB1 (ras responsive element binding protein 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Rreb1 |
| Official Name | ras responsive element binding protein 1 [Source:MGI Symbol;Acc:MGI:2443664] |
| Ensembl ID | ENSMUSG00000039087 |
| Bio databases IDs | |
| Aliases | ras responsive element binding protein 1 |
| Synonyms | 1110037N09RIK, AA414966, B930013M22RIK, FINB, HNT, LZ321, RAS RESPONSIVE ELEMENT binding protein 1, Rreb, sao, Zep-1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Rreb1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Zinc finger, C2H2 type
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- zinc finger
- transcription regulator
- double-stranded DNA binding
- nucleic acid binding
- C2H2-type zinc-finger domain
- Zinc-finger double domain
- zinc finger domain
- sequence-specific DNA binding
- transcription factor activity
- C2H2-type zinc finger
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cancer
- multiple sclerosis
- chronic obstructive pulmonary disease
- hearing loss
- insomnia
- irritable bowel syndrome
- diabetes mellitus
- chronic kidney disease
- systemic lupus erythematosus
- non-insulin-dependent diabetes mellitus
role in cell
- expression in
- apoptosis
- phosphorylation in
- binding in
- differentiation
- number
- migration by
- polyglutamylation in
- morphogenesis
- glycolysis in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- fibrillar center
- Cytoplasm
- nuclear bodies
- nuclear speckles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Rreb1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- positive regulation of brown fat cell differentiation
- positive regulation of lamellipodium morphogenesis
- positive regulation of transcription, DNA-dependent
- regulation of transcription, DNA-dependent
- transcription from RNA polymerase II promoter
- positive regulation of substrate adhesion-dependent cell spreading
- positive regulation of epithelial cell migration
- positive regulation of transcription from RNA polymerase II promoter
- positive regulation of mammary gland epithelial cell proliferation
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- extracellular vesicular exosome
- nuclear body
- cytoplasm
- nuclear speck
- fibrillar center
Molecular Function
What the gene product does at the molecular level
- metal ion binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- RNA polymerase II regulatory region sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription