Gpr1 Gene Summary [Mouse]
Predicted to enable several functions, including adipokinetic hormone binding activity; adipokinetic hormone receptor activity; and neuropeptide binding activity. Involved in glucose homeostasis. Predicted to be located in nucleoplasm. Predicted to be active in neuron projection and plasma membrane. Is expressed in several structures, including brain; early conceptus; exocrine gland; genitourinary system; and hemolymphoid system gland. Orthologous to human CMKLR2 (chemerin chemokine-like receptor 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Gpr1 |
| Official Name | G protein-coupled receptor 1 [Source:MGI Symbol;Acc:MGI:2385324] |
| Ensembl ID | ENSMUSG00000046856 |
| Bio databases IDs | |
| Aliases | G protein-coupled receptor 1 |
| Synonyms | chemerin chemokine-like receptor 2, GPR1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Gpr1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- extracellular domain
- Cholecystokinin A receptor, N-terminal
- 7 transmembrane receptor (rhodopsin family)
- protein-hormone receptor
- protein binding
- seven-transmembrane G protein-coupled receptor superfamily
- polypeptide hormone binding
Pathways
Biological processes and signaling networks where the Gpr1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- intracellular membrane-bounded organelle
- cellular membrane
- nucleoplasm
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Gpr1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- neuropeptide signaling pathway
- G-protein coupled receptor signaling pathway
- glucose homeostasis
Cellular Component
Where in the cell the gene product is active
- intracellular membrane-bounded organelle
- neuron projection
- plasma membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- G-protein coupled receptor activity
- neuropeptide binding
- adipokinetic hormone receptor activity
- protein binding
- adipokinetic hormone binding