S1pr4 Gene Summary [Mouse]
This gene encodes a member of the G-protein coupled receptor 1 family. The encoded protein is a receptor for the lysophospholipid sphingosine 1-phosphate. The encoded protein is one of the predominant sphingosine 1-phosphate G-protein coupled receptors expressed in T cells, and it plays a role in suppression of T cell proliferation, generation of cytokines, and potentially other aspects of immune activation. [provided by RefSeq, Feb 2010]
Details
| Type | Protein Coding |
| Official Symbol | S1pr4 |
| Official Name | sphingosine-1-phosphate receptor 4 [Source:MGI Symbol;Acc:MGI:1333809] |
| Ensembl ID | ENSMUSG00000044199 |
| Bio databases IDs | |
| Aliases | sphingosine-1-phosphate receptor 4 |
| Synonyms | EDG6, LPC1, S1P4, SLP4, sphingosine-1-phosphate receptor 4 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse S1pr4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- lipid binding
- 7 transmembrane receptor (rhodopsin family)
- protein binding
- seven-transmembrane G protein-coupled receptor superfamily
Pathways
Biological processes and signaling networks where the S1pr4 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- asthma
- cancer
- eczema
- ulcerative colitis
- atopic dermatitis
- Crohn disease
- diabetic nephropathy
- stroke
- androgenic alopecia
- imiquimod-induced psoriasis
role in cell
- proliferation
- differentiation
- expression in
- migration
- apoptosis
- activation in
- number
- phosphorylation in
- accumulation in
- cellular infiltration by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- presynaptic regions
- cell surface
- cellular membrane
- Mitochondria
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse S1pr4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- immune response
- G-protein coupled receptor signaling pathway
- regulation of metabolic process
- adenylate cyclase-activating G-protein coupled receptor signaling pathway
- sphingosine-1-phosphate signaling pathway
- elevation of cytosolic calcium ion concentration
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- mitochondrion
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- sphingosine-1-phosphate receptor activity
- G-protein coupled receptor activity
- protein binding
- lipid binding