Cd24a Gene Summary [Mouse]
Enables Hsp70 protein binding activity; Hsp90 protein binding activity; and carbohydrate binding activity. Involved in several processes, including chemokine receptor transport out of membrane raft; negative regulation of cytokine production; and regulation of inflammatory response to wounding. Acts upstream of or within several processes, including positive regulation of immune response; regulation of cell-cell adhesion; and regulation of lymphocyte activation. Located in several cellular components, including cell projection membrane; external side of plasma membrane; and membrane raft. Is expressed in several structures, including extraembryonic component; forebrain; genitourinary system; hemolymphoid system; and retina. Human ortholog(s) of this gene implicated in multiple sclerosis. Orthologous to human CD24 (CD24 molecule). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Processed Transcript |
| Official Symbol | Cd24a |
| Official Name | CD24a antigen [Source:MGI Symbol;Acc:MGI:88323] |
| Ensembl ID | ENSMUSG00000047139 |
| Bio databases IDs | |
| Aliases | CD24a antigen |
| Synonyms | CD24A, CD24a antigen, CD24 molecule, Heat stable antigen, HSA, Ly-52, nectadrin |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Cd24a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Hsp70 protein binding
- protein kinase binding
- heat shock protein binding
- protein binding
- carbohydrate binding
- protein tyrosine kinase activator
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- hepatocellular carcinoma
- depressive disorder
- schizophrenia
- metastasis
- experimental autoimmune encephalomyelitis
- liver cancer
- epithelial cancer
- rheumatoid arthritis
- plaque psoriasis
role in cell
- activation
- apoptosis
- proliferation
- expression in
- growth
- migration
- quantity
- differentiation
- formation
- accumulation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- detergent-insoluble membrane fraction
- motile cilia
- intracellular membrane-bounded organelle
- Cytoplasm
- cilia
- cell surface
- cellular membrane
- plasma membrane extracellular face
- apical membrane
- membrane rafts
- microvilli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Cd24a gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of MAP kinase activity
- regulation of MAPK cascade
- response to estrogen stimulus
- regulation of cell-cell adhesion
- intrinsic apoptotic signaling pathway
- cholesterol homeostasis
- response to molecule of bacterial origin
- response to hypoxia
- Wnt receptor signaling pathway
- cell migration
- chemokine receptor transport out of membrane raft
- T cell costimulation
- respiratory burst
- positive regulation of activated T cell proliferation
- regulation of phosphorylation
- elevation of cytosolic calcium ion concentration
- negative regulation of transforming growth factor beta3 production
- cell activation
- regulation of epithelial cell differentiation
- positive regulation of nephron tubule epithelial cell differentiation
- immune response-regulating cell surface receptor signaling pathway
- glomerular visceral epithelial cell differentiation
- B cell receptor transport into membrane raft
- glomerular parietal epithelial cell differentiation
- regulation of cytokine-mediated signaling pathway
Cellular Component
Where in the cell the gene product is active
- intracellular membrane-bounded organelle
- membrane raft
- membrane
- external side of plasma membrane
- cell surface
Molecular Function
What the gene product does at the molecular level
- protein kinase binding
- protein binding
- protein tyrosine kinase activator activity