CD24 Gene Summary [Human]
This gene encodes a sialoglycoprotein that is expressed on mature granulocytes and B cells and modulates growth and differentiation signals to these cells. The precursor protein is cleaved to a short 32 amino acid mature peptide which is anchored via a glycosyl phosphatidylinositol (GPI) link to the cell surface. This gene was missing from previous genome assemblies, but is properly located on chromosome 6. Non-transcribed pseudogenes have been designated on chromosomes 1, 15, 20, and Y. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014]
Details
| Type | Protein Coding |
| Official Symbol | CD24 |
| Official Name | CD24 molecule [Source:HGNC Symbol;Acc:HGNC:1645] |
| Ensembl ID | ENSG00000272398 |
| Bio databases IDs | |
| Aliases | CD24 molecule |
| Synonyms | CD24A, CD24a antigen, CD24 molecule, Heat stable antigen, HSA, Ly-52, nectadrin |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human CD24 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Hsp70 protein binding
- protein kinase binding
- heat shock protein binding
- protein binding
- carbohydrate binding
- protein tyrosine kinase activator
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- hepatocellular carcinoma
- depressive disorder
- schizophrenia
- metastasis
- experimental autoimmune encephalomyelitis
- liver cancer
- epithelial cancer
- rheumatoid arthritis
- plaque psoriasis
role in cell
- activation
- apoptosis
- proliferation
- expression in
- growth
- migration
- quantity
- differentiation
- formation
- accumulation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- detergent-insoluble membrane fraction
- motile cilia
- intracellular membrane-bounded organelle
- Cytoplasm
- cilia
- cell surface
- cellular membrane
- plasma membrane extracellular face
- apical membrane
- membrane rafts
- microvilli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human CD24 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of MAP kinase activity
- regulation of MAPK cascade
- response to estrogen stimulus
- regulation of cell-cell adhesion
- intrinsic apoptotic signaling pathway
- cholesterol homeostasis
- response to molecule of bacterial origin
- response to hypoxia
- Wnt receptor signaling pathway
- cell migration
- chemokine receptor transport out of membrane raft
- T cell costimulation
- respiratory burst
- positive regulation of activated T cell proliferation
- regulation of phosphorylation
- elevation of cytosolic calcium ion concentration
- negative regulation of transforming growth factor beta3 production
- cell activation
- regulation of epithelial cell differentiation
- positive regulation of nephron tubule epithelial cell differentiation
- immune response-regulating cell surface receptor signaling pathway
- glomerular visceral epithelial cell differentiation
- B cell receptor transport into membrane raft
- glomerular parietal epithelial cell differentiation
- regulation of cytokine-mediated signaling pathway
Cellular Component
Where in the cell the gene product is active
- intracellular membrane-bounded organelle
- membrane raft
- membrane
- external side of plasma membrane
- cell surface
Molecular Function
What the gene product does at the molecular level
- protein kinase binding
- protein binding
- protein tyrosine kinase activator activity