Dmbt1 Gene Summary [Mouse]
Enables zymogen binding activity. Involved in defense response to Gram-negative bacterium and defense response to Gram-positive bacterium. Acts upstream of or within inner cell mass cell proliferation; positive regulation of epithelial cell differentiation; and response to bacterium. Located in extracellular matrix and zymogen granule membrane. Is expressed in several structures, including blastocyst; central nervous system; genitourinary system; gut; and notochord. Human ortholog(s) of this gene implicated in glioblastoma. Orthologous to human DMBT1 (deleted in malignant brain tumors 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Dmbt1 |
| Official Name | deleted in malignant brain tumors 1 [Source:MGI Symbol;Acc:MGI:106210] |
| Ensembl ID | ENSMUSG00000047517 |
| Bio databases IDs | |
| Aliases | deleted in malignant brain tumors 1 |
| Synonyms | CRP, CRP-[a], CRP-[b], Crpd, DBMT1, deleted in malignant brain tumors 1, deleted in malignant brain tumours 1, gp300, GP340, hensin, LOC100361701, LOC100911344, LOC691969, muclin, p80, SAG, SALSA |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Dmbt1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- calcium-dependent protein binding
- Scavenger receptor cysteine-rich domain
- signaling receptor activity
- enzyme binding
- protein binding
- lipopolysaccharide binding
- glycosaminoglycan binding
- DNA binding
- Scavenger receptor Cys-rich
- CUB
- binding protein
- scavenger receptor
- Zona pellucida-like domain
- Zona pellucida (ZP) domain
- transmembrane receptor
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- Crohn disease
- glioblastoma
- glioblastoma cancer
- glioma formation
- brain cancer
- malignant brain neoplasm
- distal renal tubular acidosis
- pilocytic astrocytoma
- colitis
role in cell
- differentiation
- migration
- quantity
- respiratory burst by
- hemagglutination
- conversion
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Cytoplasm
- cell surface
- Extracellular Space
- intracellular space
- apical compartment
- basal compartment
- cellular membrane
- vesicles
- apical membrane
- zymogen granules
- extracellular matrix
- phagosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Dmbt1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- epithelial cell differentiation
- vesicle-mediated transport
- induction of bacterial agglutination
- defense response to Gram-negative bacterium
- innate immune response
- protein transport
- defense response to virus
- defense response
- defense response to Gram-positive bacterium
Cellular Component
Where in the cell the gene product is active
- extracellular space
- extracellular vesicular exosome
- cytoplasm
- phagocytic vesicle membrane
- extracellular matrix
- extracellular region
- zymogen granule membrane
Molecular Function
What the gene product does at the molecular level
- zymogen binding
- protein binding
- scavenger receptor activity
- calcium-dependent protein binding