Efnb2 Gene Summary [Mouse]
Enables signaling receptor binding activity. Involved in several processes, including adherens junction organization; positive regulation of cardiac muscle cell differentiation; and regulation of postsynaptic neurotransmitter receptor internalization. Acts upstream of or within several processes, including negative regulation of keratinocyte proliferation; positive regulation of aorta morphogenesis; and vasculature development. Located in plasma membrane. Is active in Schaffer collateral - CA1 synapse; glutamatergic synapse; and postsynaptic density membrane. Is expressed in several structures, including alimentary system; brain; cardiovascular system; sensory organ; and urinary system. Human ortholog(s) of this gene implicated in colon carcinoma; colorectal carcinoma; and esophagus squamous cell carcinoma. Orthologous to human EFNB2 (ephrin B2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Efnb2 |
| Official Name | ephrin B2 [Source:MGI Symbol;Acc:MGI:105097] |
| Ensembl ID | ENSMUSG00000001300 |
| Bio databases IDs | |
| Aliases | ephrin B2 |
| Synonyms | ELF-2, ephrin B2, Epl5, EPLG5, HTKL, LERK-5, NLERK-1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Efnb2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- extracellular domain
- Ephrin
- Cupredoxin superfamily
- cytoplasmic domain
- ectodomain
- intracellular domain
- ephrin receptor binding
- protein binding
- receptor binding
- cytosolic tail domain
Pathways
Biological processes and signaling networks where the Efnb2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- cancer
- metastasis
- advanced cancer
- malignant thyroid gland neoplasm
- thyroid cancer
- colorectal cancer
- growth failure
- prostate cancer
- papillary thyroid carcinoma
role in cell
- phosphorylation in
- expression in
- activation in
- apoptosis
- growth
- proliferation
- migration
- cell death
- quantity
- production in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- glutaminergic synapse
- cell surface
- cellular membrane
- presynaptic membrane
- synaptic membrane
- synapse
- dendrites
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Efnb2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- viral entry into host cell
- keratinocyte proliferation
- adherens junction organization
- T cell costimulation
- positive regulation of cell proliferation
- cell-cell signaling
- venous blood vessel morphogenesis
- axon guidance
- blood vessel morphogenesis
- cell migration involved in sprouting angiogenesis
- anatomical structure morphogenesis
- cell adhesion
- organ morphogenesis
- positive regulation of cardiac muscle cell differentiation
- negative regulation of keratinocyte proliferation
- negative regulation of neuron projection development
- nephric duct morphogenesis
- lymph vessel development
- ephrin receptor signaling pathway
- regulation of chemotaxis
Cellular Component
Where in the cell the gene product is active
- presynaptic membrane
- adherens junction
- focal adhesion
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- ephrin receptor binding
- viral receptor activity