Apof Gene Summary [Mouse]
Acts upstream of or within cholesterol efflux; cholesterol metabolic process; and triglyceride metabolic process. Predicted to be part of high-density lipoprotein particle and low-density lipoprotein particle. Predicted to be active in extracellular space. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; hemolymphoid system gland; and liver. Orthologous to human APOF (apolipoprotein F). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Apof |
| Official Name | apolipoprotein F [Source:MGI Symbol;Acc:MGI:104539] |
| Ensembl ID | ENSMUSG00000047631 |
| Bio databases IDs | |
| Aliases | apolipoprotein F |
| Synonyms | apolipoprotein F, LTIP |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Apof often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- lipid transporter
- cholesterol binding
- Apolipoprotein F
- protein binding
- receptor binding
Pathways
Biological processes and signaling networks where the Apof gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- liver cancer
- aortic valve calcification
- hepatocellular carcinoma
- epithelial cancer
- hypertriglyceridemia
- nonalcoholic steatohepatitis
- hypercholesterolemia
- hepatitis B virus-related hepatocellular carcinoma
regulates
- triacylglycerol
- HDL/cholesterol
- lipid
- cholesterol
- cholesterol ester
- CETP
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Apof gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- lipid transport
- lipid metabolic process
- cholesterol metabolic process
Cellular Component
Where in the cell the gene product is active
- extracellular space
- high-density lipoprotein particle
- low-density lipoprotein particle
Molecular Function
What the gene product does at the molecular level
- cholesterol binding
- lipid transporter activity
- receptor binding