Timm8a1 Gene Summary [Mouse]
Predicted to enable identical protein binding activity and zinc ion binding activity. Predicted to be involved in protein targeting to mitochondrion. Located in mitochondrion. Is expressed in cap mesenchyme; early tubule; lung mesenchyme; and renal interstitium. Human ortholog(s) of this gene implicated in deafness-dystonia-optic neuronopathy syndrome and dystonia. Orthologous to human TIMM8A (translocase of inner mitochondrial membrane 8A). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Timm8a1 |
| Official Name | translocase of inner mitochondrial membrane 8A1 [Source:MGI Symbol;Acc:MGI:1353433] |
| Ensembl ID | ENSMUSG00000048007 |
| Bio databases IDs | |
| Aliases | translocase of inner mitochondrial membrane 8A1 |
| Synonyms | DDP, DDP1, DFN1, DXHXS1274E, Fci-12, MGC12262, MTS, TIM8, Tim8a, Timm8a1, translocase of inner mitochondrial membrane 8A, translocase of inner mitochondrial membrane 8A1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Timm8a1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- zinc ion binding
- coiled-coil domain
- Tim10/DDP family zinc finger
- protein binding
- zinc finger domain
- identical protein binding
- transporter
Pathways
Biological processes and signaling networks where the Timm8a1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hereditary disorder
- Mohr-Tranebjaerg syndrome
- auditory neuropathy
- infection by HIV-1
- productive infection by HIV-1
regulates
- Tim23
- TIMM23B
- TIMM8A
- TIMM13
role in cell
- growth
- depletion
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- mitochondrial fraction
- Mitochondria
- mitochondrial intermembrane space
- mitochondrial inner membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Timm8a1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- nervous system development
- protein import into mitochondrial inner membrane
Cellular Component
Where in the cell the gene product is active
- mitochondrial intermembrane space
- mitochondrial intermembrane space protein transporter complex
- mitochondrion
- mitochondrial inner membrane
Molecular Function
What the gene product does at the molecular level
- zinc ion binding
- identical protein binding
- protein binding