Stam Gene Summary [Mouse]
Predicted to enable ubiquitin-like protein ligase binding activity. Predicted to be involved in positive regulation of exosomal secretion; protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway; and regulation of extracellular exosome assembly. Predicted to be located in cytosol and intracellular membrane-bounded organelle. Predicted to be part of ESCRT-0 complex. Is expressed in dorsal root ganglion; future spinal cord; hippocampus; sciatic nerve; and spinal cord. Orthologous to human STAM (signal transducing adaptor molecule). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Stam |
| Official Name | signal transducing adaptor molecule (SH3 domain and ITAM motif) 1 [Source:MGI Symbol;Acc:MGI:1329014] |
| Ensembl ID | ENSMUSG00000026718 |
| Bio databases IDs | |
| Aliases | signal transducing adaptor molecule (SH3 domain and ITAM motif) 1 |
| Synonyms | HSE1, RGD1564499, signal transducing adaptor molecule, signal transducing adaptor molecule (SH3 domain and ITAM motif) 1, STAM-1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Stam often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- GAT_SF
- Ubiquitin-interacting motif
- tyrosine cluster region
- Ubiquitin interaction motif
- ubiquitin binding domain
- VHS, ENTH and ANTH domain superfamily
- enzyme binding
- coiled-coil domain
- protein binding
- Src Homology 3 domain superfamily
- Sh3 domain binding motif
- Domain present in VPS-27, Hrs and STAM
Pathways
Biological processes and signaling networks where the Stam gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- allergy
- seizures
- growth failure
- priapism
- gliosis
- infection by HBV genotype D
role in cell
- cell viability
- quantity
- proliferation
- activation in
- degradation in
- dissociation in
- binding in
- development
- chemotaxis
- number
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- membrane fraction
- intracellular membrane-bounded organelle
- cellular membrane
- endosomes
- Mitochondria
- cytosol
- caveolae
- synaptosomes
- early endosomes
- exosomes
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Stam gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
- membrane fission
- signal transduction
- macroautophagy
Cellular Component
Where in the cell the gene product is active
- early endosome membrane
- intracellular membrane-bounded organelle
- ESCRT-0 complex
- cytosol
Molecular Function
What the gene product does at the molecular level
- protein binding
- ubiquitin binding
- phosphatidylinositol binding
- small conjugating protein ligase binding