Tgm2 Gene Summary [Mouse]
Enables protein-glutamine gamma-glutamyltransferase activity. Involved in intracellular calcium ion homeostasis; positive regulation of cell adhesion; and regulation of apoptotic cell clearance. Acts upstream of or within branching involved in salivary gland morphogenesis and salivary gland cavitation. Located in collagen-containing extracellular matrix. Is expressed in several structures, including alimentary system; bone; central nervous system; genitourinary system; and sensory organ. Used to study maturity-onset diabetes of the young. Orthologous to human TGM2 (transglutaminase 2). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tgm2 |
| Official Name | transglutaminase 2, C polypeptide [Source:MGI Symbol;Acc:MGI:98731] |
| Ensembl ID | ENSMUSG00000037820 |
| Bio databases IDs | |
| Aliases | transglutaminase 2, C polypeptide |
| Synonyms | Ftg, G[a]h, G(h), hTG2, TG2, TGA2, TGASE, TGase2, TGase C, TgaseII, TGC, TG(C), TGII, TISSUE TRANSGLUTAMINASE, TISSUE TRANSGLUTAMINASE 2, Tranglutaminase 2, Transglutaminase, TRANSGLUTAMINASE 2, transglutaminase 2, C polypeptide, tTG, tTGas, T-Tgase |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Tgm2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- N-acyltransferase
- catalytic domain
- calcium ion binding
- heparin binding domain
- enzyme binding
- protein domain specific binding
- enzyme
- protein binding
- Transglutaminase family, C-terminal ig like domain
- transaminase
- core domain, functional
- identical protein binding
- GTP binding
- Transglutaminase-like superfamily
- Transglutaminase/protease-like homologues
- Bcl-2 homology 3 domain
- protein-glutamine gamma-glutamyltransferase
- aminotransferase domain
- protein-glutamine glutaminase
- Transglutaminase family
Pathways
Biological processes and signaling networks where the Tgm2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- metastasis
- neoplasia
- seizures
- renal cancer
- systemic lupus erythematosus
- psoriasis
- colorectal cancer
- Alzheimer disease
- cancer
- tumorigenesis
role in cell
- differentiation
- survival
- production in
- cell death
- condensation
- condensation in
- binding
- proliferation
- expression in
- phosphorylation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- membrane fraction
- detergent resistant lipid raft fraction
- invadopodia
- cell-matrix contacts
- cell surface
- cell borders
- Extracellular Space
- cell periphery
- perinuclear region
- cellular tail
- membrane surface
- cellular membrane
- Nucleus
- Plasma Membrane
- Mitochondria
- intercellular junctions
- cytosol
- sinusoidal membrane
- nucleosomes
- extracellular matrix
- cell membrane leading edge
- chromatin
- cell-matrix adherens junctions
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Tgm2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- salivary gland cavitation
- dopamine secretion
- reduction of endoplasmic reticulum calcium ion concentration
- apoptotic cell clearance
- regulation of apoptotic process
- positive regulation of cell adhesion
- phospholipase C-activating G-protein coupled receptor signaling pathway
- branching involved in salivary gland morphogenesis
- positive regulation of GTPase activity
- bone development
- positive regulation of small GTPase mediated signal transduction
- chromatin remodeling
- elevation of mitochondrial calcium ion concentration
- positive regulation of apoptotic process
- proteolysis
- cellular response to cocaine
- protein deamination
- gene expression
- positive regulation of neurogenesis
- regulation of apoptotic cell clearance
- peptide cross-linking
Cellular Component
Where in the cell the gene product is active
- nucleus
- extracellular vesicular exosome
- perinuclear region of cytoplasm
- focal adhesion
- mitochondrion
- cytosol
- endoplasmic reticulum
- extracellular matrix
- nucleosome
- chromatin
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- GTP binding
- protein-glutamine gamma-glutamyltransferase activity
- protein binding
- calcium ion binding
- peptidase activity
- protein-glutamine glutaminase activity