Amigo2 Gene Summary [Mouse]
Acts upstream of or within positive regulation of synapse assembly. Predicted to be located in nucleus and plasma membrane. Predicted to be active in membrane. Is expressed in several structures, including brain; branchial arch; cranial ganglion; genitourinary system; and retina. Orthologous to human AMIGO2 (adhesion molecule with Ig like domain 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Amigo2 |
| Official Name | adhesion molecule with Ig like domain 2 [Source:MGI Symbol;Acc:MGI:2145995] |
| Ensembl ID | ENSMUSG00000048218 |
| Bio databases IDs | |
| Aliases | adhesion molecule with Ig like domain 2 |
| Synonyms | AC004010, adhesion molecule with Ig like domain 2, ALI1, Alivin, DEGA, LOC100364402, LOC102724147 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Amigo2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- protein phosphatase 1 regulatory subunit 42
- immunoglobulin domain
- Immunoglobulin like
- Immunoglobulin I-set domain
- Leucine rich repeat
- Leucine rich repeat C-terminal domain
- protein binding
- Leucine Rich repeats (2 copies)
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- metabolic syndrome X
role in cell
- apoptosis
- phosphorylation in
- survival
- activation in
- adhesion
- cisplatin sensitivity
- tubulation
- pyroptosis
- molecular cleavage in
- inactivation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- plasma membrane fraction
- nuclear fraction
- cell surface
- cellular membrane
- Nucleus
- perikaryon
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Amigo2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- heterophilic cell-cell adhesion
- negative regulation of programmed cell death
- brain development
- homophilic cell adhesion
- positive regulation of synapse assembly
Cellular Component
Where in the cell the gene product is active
- nucleus
- membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding