Rhoq Gene Summary [Mouse]
Predicted to enable several functions, including GBD domain binding activity; GTP binding activity; and profilin binding activity. Involved in cellular response to insulin stimulus; cortical actin cytoskeleton organization; and negative regulation of protein localization to plasma membrane. Acts upstream of or within regulation of cell shape. Located in membrane raft. Is expressed in dentate gyrus subgranular zone; lower leg bone; and telencephalon. Orthologous to human RHOQ (ras homolog family member Q). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Rhoq |
| Official Name | ras homolog family member Q [Source:MGI Symbol;Acc:MGI:1931553] |
| Ensembl ID | ENSMUSG00000024143 |
| Bio databases IDs | |
| Aliases | ras homolog family member Q |
| Synonyms | ARHQ, HEL-S-42, ras homolog family member Q, RASL7A, Rhot, TC10, TC10A, Tc10alpha, TC10 beta, Tc10 α, TC10 β |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Rhoq often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Small GTPase of the Ras superfamily (ill-defined subfamily)
- Ras family
- GTPase
- protein domain specific binding
- enzyme
- protein binding
- prenylation site
- Ras subfamily of RAS small GTPases
- profilin binding
- ADP-ribosylation factor family
- small GTP-binding protein domain
- GTPase domain
- Rab subfamily of small GTPases
- Ras of Complex, Roc, domain of DAPkinase
- Rho (Ras homology) subfamily of Ras-like small GTPases
- P-loop containing Nucleoside Triphosphate Hydrolases
Pathways
Biological processes and signaling networks where the Rhoq gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- Actin Nucleation by ARP-WASP Complex
- Cholecystokinin/Gastrin-mediated Signaling
- CXCR4 Signaling
- Germ Cell-Sertoli Cell Junction Signaling
- Glioblastoma Multiforme Signaling
- Glioma Invasiveness Signaling
- Gαq Signaling
- HMGB1 Signaling
- IL-8 Signaling
- ILK Signaling
- Insulin Receptor Signaling
- Integrin Signaling
- mTOR Signaling
- Production of Nitric Oxide and Reactive Oxygen Species in Macrophages
- Regulation of Actin-based Motility by Rho
- Semaphorin Signaling in Neurons
- Serotonin Receptor Signaling
- Sphingosine-1-phosphate Signaling
- Tec Kinase Signaling
- Thrombin Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Alzheimer disease
- colorectal cancer
- severe acute respiratory syndrome
role in cell
- expression in
- quantity
- differentiation
- phosphorylation in
- disruption
- proliferation
- formation
- assembly
- insertion
- outgrowth
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- plasma membrane fraction
- Cytoplasm
- perinuclear region
- actin filaments
- caveolae
- Golgi membrane
- secretory granules
- membrane rafts
- detergent-soluble fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Rhoq gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of cell shape
- signal transduction
- small GTPase mediated signal transduction
- insulin receptor signaling pathway
- establishment or maintenance of cell polarity
- GTP metabolic process
- positive regulation of filopodium assembly
- actin filament organization
- positive regulation of glucose import
- positive regulation of transcription from RNA polymerase II promoter
- endocytosis
- cellular response to insulin stimulus
- cortical actin cytoskeleton organization
- regulation of actin cytoskeleton organization
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- membrane raft
- Golgi-associated vesicle membrane
- actin filament
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- GTP binding
- protein kinase binding
- GBD domain binding
- protein binding
- GTPase activity
- profilin binding