Kcnb2 Gene Summary [Mouse]
Predicted to enable several functions, including delayed rectifier potassium channel activity; protein heterodimerization activity; and transmembrane transporter binding activity. Predicted to be involved in action potential; potassium ion transmembrane transport; and protein localization to plasma membrane. Predicted to be located in neuronal cell body membrane. Predicted to be part of voltage-gated potassium channel complex. Predicted to be active in dendrite; membrane; and neuronal cell body. Is expressed in several structures, including central nervous system; genitourinary system; hemolymphoid system gland; liver; and sensory organ. Human ortholog(s) of this gene implicated in alcohol dependence. Orthologous to human KCNB2 (potassium voltage-gated channel subfamily B member 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Kcnb2 |
| Official Name | potassium voltage gated channel, Shab-related subfamily, member 2 [Source:MGI Symbol;Acc:MGI:99632] |
| Ensembl ID | ENSMUSG00000092083 |
| Bio databases IDs | |
| Aliases | potassium voltage gated channel, Shab-related subfamily, member 2 |
| Synonyms | 9630047L19RIK, KV2.2, potassium voltage gated channel, Shab-related subfamily, member 2, potassium voltage-gated channel subfamily B member 2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Kcnb2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- delayed rectifier potassium channel
- Ion transport protein
- Kv2 voltage-gated K+ channel
- Broad-Complex, Tramtrack and Bric a brac
- BTB_POZ
- ion channel binding
- protein binding
- ion channel
- protein heterodimerization
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- multiple sclerosis
- dementia
- coronary artery disease
- secondary progressive multiple sclerosis
- nerve injury
- acute myeloid leukemia
- colorectal cancer
- non-insulin-dependent diabetes mellitus
- rheumatic fever
- relapsing-remitting multiple sclerosis
regulates
- insulin
- SST
- K+
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cellular membrane
- perikaryon
- dendrites
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Kcnb2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- potassium ion transport
- potassium ion transmembrane transport
- protein homooligomerization
- regulation of action potential
- protein localization in plasma membrane
- regulation of smooth muscle contraction
Cellular Component
Where in the cell the gene product is active
- dendrite
- voltage-gated potassium channel complex
- membrane
- neuronal cell body membrane
- neuronal cell body
- perikaryon
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- protein heterodimerization activity
- delayed rectifier potassium channel activity