Npy4r Gene Summary [Mouse]
Enables pancreatic polypeptide receptor activity and peptide YY receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Predicted to be active in neuron projection and plasma membrane. Orthologous to several human genes including NPY4R (neuropeptide Y receptor Y4). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Npy4r |
| Official Name | neuropeptide Y receptor Y4 [Source:MGI Symbol;Acc:MGI:105374] |
| Ensembl ID | ENSMUSG00000048337 |
| Bio databases IDs | |
| Aliases | neuropeptide Y receptor Y4 |
| Synonyms | LOC101060446, LOC124906894, neuropeptide Y receptor Y4, NPYR-D, NYYR-D, PP1, PPYR1, Y4 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Npy4r often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- peptide YY receptor
- pancreatic polypeptide receptor
- peptide binding
- Cholecystokinin A receptor, N-terminal
- transmembrane domain
- 7 transmembrane receptor (rhodopsin family)
- seven-transmembrane G protein-coupled receptor superfamily
- polypeptide hormone binding
Pathways
Biological processes and signaling networks where the Npy4r gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- obesity
- nonalcoholic fatty liver disease-related cirrhosis
- hyperphagia
role in cell
- number
- function
- activity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- membrane fraction
- cell surface
- cellular membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Npy4r gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- neuropeptide signaling pathway
- G-protein coupled receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- membrane
- neuron projection
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- G-protein coupled receptor activity
- neuropeptide binding
- pancreatic polypeptide receptor activity
- peptide hormone binding