Hcar1 Gene Summary [Mouse]
Enables G protein-coupled receptor activity. Involved in G protein-coupled receptor signaling pathway and negative regulation of lipid catabolic process. Is active in membrane. Is expressed in retina ganglion cell layer and retina layer. Orthologous to human HCAR1 (hydroxycarboxylic acid receptor 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Hcar1 |
| Official Name | hydrocarboxylic acid receptor 1 [Source:MGI Symbol;Acc:MGI:2441671] |
| Ensembl ID | ENSMUSG00000049241 |
| Bio databases IDs | |
| Aliases | hydrocarboxylic acid receptor 1 |
| Synonyms | FKSG80, GPR104, GPR81, HCA1, hydrocarboxylic acid receptor 1, hydroxycarboxylic acid receptor 1, LACR1, LOC687572, TA-GPCR |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Hcar1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- Cholecystokinin A receptor, N-terminal
- 7 transmembrane receptor (rhodopsin family)
- seven-transmembrane G protein-coupled receptor superfamily
Pathways
Biological processes and signaling networks where the Hcar1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- breast cancer
- pancreatic cancer
- metastasis
role in cell
- cell death
- apoptosis
- proliferation
- activation in
- accumulation in
- expression in
- migration
- differentiation
- invasion by
- production in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- organelle
- cell surface
- cellular membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Hcar1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- G-protein coupled receptor signaling pathway
- negative regulation of lipid catabolic process
Cellular Component
Where in the cell the gene product is active
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- G-protein coupled receptor activity