Dcaf7 Gene Summary [Mouse]
Predicted to be involved in protein ubiquitination. Predicted to be located in cytosol; nuclear body; and nuclear matrix. Predicted to be part of Cul4-RING E3 ubiquitin ligase complex. Predicted to be active in nucleus. Is expressed in brain; cerebral cortex subventricular zone; cortical plate; embryo; and limb. Orthologous to human DCAF7 (DDB1 and CUL4 associated factor 7). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Dcaf7 |
| Official Name | DDB1 and CUL4 associated factor 7 [Source:MGI Symbol;Acc:MGI:1919083] |
| Ensembl ID | ENSMUSG00000049354 |
| Bio databases IDs | |
| Aliases | DDB1 and CUL4 associated factor 7 |
| Synonyms | 1700012F10Rik, 2610037L01Rik, AN11, DDB1 and CUL4 associated factor 7, HAN11, RGD1305140, SWAN-1, WDR68 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Dcaf7 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- WD40 repeats
- protein binding activity, bridging
- WD domain, G-beta repeat
- WD40
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- Alzheimer disease
- metabolic syndrome X
regulates
- MTORC1
- LIG1
role in cell
- apoptosis
- activation in
- degradation in
- ribociclib sensitivity
- palbociclib sensitivity
- ipatasertib sensitivity
- CSN5i-3 resistance
- tanespimycin resistance
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- cytosol
- nucleoplasm
- nuclear bodies
- nuclear matrix
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Dcaf7 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein ubiquitination
Cellular Component
Where in the cell the gene product is active
- nucleus
- nuclear body
- cytoplasm
- nuclear matrix
- cytosol
- macromolecular complex
- CUL4 RING ubiquitin ligase complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- protein binding, bridging