Cltc Gene Summary [Mouse]
Enables protein kinase binding activity. Predicted to be involved in several processes, including amyloid-beta clearance by transcytosis; endocytosis; and negative regulation of hyaluronan biosynthetic process. Predicted to act upstream of or within mitotic spindle assembly. Located in clathrin-coated pit. Part of membrane coat. Is active in several cellular components, including photoreceptor ribbon synapse; postsynaptic endocytic zone; and presynaptic endocytic zone membrane. Is expressed in several structures, including brain; early embryo; placenta; and unsegmented mesenchyme. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder 56. Orthologous to human CLTC (clathrin heavy chain). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cltc |
| Official Name | clathrin, heavy polypeptide (Hc) [Source:MGI Symbol;Acc:MGI:2388633] |
| Ensembl ID | ENSMUSG00000047126 |
| Bio databases IDs | |
| Aliases | clathrin, heavy polypeptide (Hc) |
| Synonyms | 3110065L21Rik, CHC, CHC17, CHC22, Clathrin Hc, Clathrin Heavy Chain, CLH-17, CLTCL2, Hc, MRD56 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Cltc often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Clathrin-H-link
- peptide binding
- protein kinase binding
- light chain binding domain
- protease binding
- heat shock protein binding
- clathrin binding
- Clathrin propeller repeat
- protein domain specific binding
- linker domain
- low-density lipoprotein receptor binding
- protein binding
- globular tail domain
- terminal domain
- clathrin trimerization domain
- distal domain
- ankyrin binding
- double-stranded RNA binding
- Region in Clathrin and VPS
- Clathrin heavy chain repeat homology
- Clathrin, heavy-chain linker
Pathways
Biological processes and signaling networks where the Cltc gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Parkinson disease
- tumorigenesis
- autosomal dominant mental retardation type 56
- hereditary disorder
- nephrosis
- neurodevelopmental disorder
- neonatal late-onset sepsis
- Noonan syndrome 3
- global developmental delay
- exfoliative glaucoma
role in cell
- expression in
- transformation
- apoptosis
- mitosis
- cell death
- growth
- phosphorylation in
- proliferation
- morphology
- production in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- interchromatin granule cluster fractions
- plasma membrane fraction
- intracellular membrane fractions
- myelin enriched fraction
- nuclear fraction
- raft fractions
- membrane fraction
- detergent resistant lipid raft fraction
- glutaminergic synapse
- endoplasmic reticulum mitochondria contact site
- endocytic vesicle membrane
- intracellular membrane-bounded organelle
- spindle apparatus
- periactive zone
- extracellular vesicles
- Cytoplasm
- perinuclear region
- cellular membrane
- Nucleus
- endosomes
- vesicles
- centrosome
- lysosome
- Mitochondria
- granules
- cytosol
- caveolar membranes
- apical membrane
- synaptic membrane
- basolateral membrane
- Golgi buds
- trans Golgi network
- lysosome membrane
- endosomal membrane
- nuclear foci
- spindle fibers
- growth cone
- sarcolemma
- myotendinous junctions
- transverse tubules
- membrane rafts
- clathrin-coated pits
- cell membrane leading edge
- mitotic spindle
- ribbon synapse
- Golgi vesicles
- exosomes
- clathrin-coated vesicles
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Cltc gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- transferrin transport
- negative regulation of hyaluronan biosynthetic process
- retrograde transport, endosome to Golgi
- intracellular protein transport
- receptor-mediated endocytosis
- regulation of mitotic spindle organization
- mitotic cell cycle
- clathrin-mediated endocytosis
- cell division
- clathrin coat assembly
- autophagy
- osteoblast differentiation
- receptor internalization
- clathrin coat disassembly
Cellular Component
Where in the cell the gene product is active
- endolysosome membrane
- clathrin coat of trans-Golgi network vesicle
- clathrin-coated endocytic vesicle
- plasma membrane
- lysosome
- clathrin coat
- endosome
- extracellular vesicular exosome
- clathrin-coated endocytic vesicle membrane
- mitotic spindle
- focal adhesion
- melanosome
- membrane
- spindle
- clathrin coat of coated pit
- cytosol
- macromolecular complex
- clathrin-coated vesicle
- clathrin complex
- trans-Golgi network membrane
Molecular Function
What the gene product does at the molecular level
- protein kinase binding
- clathrin light chain binding
- RNA binding
- low-density lipoprotein particle receptor binding
- protein binding
- double-stranded RNA binding
- structural molecule activity