Slc35d3 Gene Summary [Mouse]
Enables UDP-glucose transmembrane transporter activity and protein-macromolecule adaptor activity. Involved in UDP-glucose transmembrane transport; platelet dense granule organization; and positive regulation of autophagy. Acts upstream of or within energy homeostasis and positive regulation of protein exit from endoplasmic reticulum. Located in early endosome and endoplasmic reticulum. Is active in early endosome membrane. Is expressed in midbrain mantle layer and thymus primordium. Orthologous to human SLC35D3 (solute carrier family 35 member D3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Slc35d3 |
| Official Name | solute carrier family 35, member D3 [Source:MGI Symbol;Acc:MGI:1923407] |
| Ensembl ID | ENSMUSG00000050473 |
| Bio databases IDs | |
| Aliases | solute carrier family 35, member D3 |
| Synonyms | 6230421J19Rik, FRCL1, solute carrier family 35 member D3, solute carrier family 35, member D3 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Slc35d3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein binding activity, bridging
- EamA-like transporter family
- protein binding
- UDP-glucose transporter
- transporter
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- obesity
- metabolic syndrome X
- Huntington disease
- Parkinson disease
role in cell
- production in
- autophagy by
- accumulation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- synaptic vesicle membrane
- Endoplasmic Reticulum
- endosomal membrane
- early endosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Slc35d3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- UDP-glucose transport
- platelet dense granule organization
- positive regulation of autophagy
- transmembrane transport
- protein exit from endoplasmic reticulum
- energy homeostasis
- positive regulation of protein exit from endoplasmic reticulum
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- early endosome membrane
- Golgi apparatus
- endoplasmic reticulum
- synaptic vesicle membrane
Molecular Function
What the gene product does at the molecular level
- antiporter activity
- UDP-glucose transmembrane transporter activity
- protein binding, bridging