Gp1bb Gene Summary [Mouse]
Predicted to enable identical protein binding activity. Involved in blood coagulation and megakaryocyte development. Predicted to be located in plasma membrane. Predicted to be part of glycoprotein Ib-IX-V complex. Is expressed in central nervous system; heart; male reproductive gland or organ; retina; and yolk sac. Used to study Bernard-Soulier syndrome. Human ortholog(s) of this gene implicated in Bernard-Soulier syndrome. Orthologous to human GP1BB (glycoprotein Ib platelet subunit beta). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Gp1bb |
| Official Name | glycoprotein Ib, beta polypeptide [Source:MGI Symbol;Acc:MGI:107852] |
| Ensembl ID | ENSMUSG00000050761 |
| Bio databases IDs | |
| Aliases | glycoprotein Ib, beta polypeptide |
| Synonyms | BDPLT1, BS, CD42C, glycoprotein Ib, beta polypeptide, glycoprotein Ib platelet subunit beta, glycoprotein Ib platelet subunit β, glycoprotein Ib, β polypeptide, GP1B beta, GP1BP, GP1B β, GPIBB, GPIbbeta, GPIb β |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Gp1bb often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- cytoplasmic domain
- Leucine rich repeat C-terminal domain
- protein binding
- Leucine rich repeat N-terminal domain
- identical protein binding
- phosphorylation site
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- essential thrombocythemia
- obesity
- systemic lupus erythematosus
- Bernard-Soulier syndrome
- androgenic alopecia
- macrothrombocytopenia
- thrombocytopenia
- global developmental delay with intellectual disability
- Bernard-Soulier syndrome type B
- neonatal alloimmune thrombocytopenia
role in cell
- activation
- adhesion
- abnormal morphology
- volume
- exposure in
- mobilization in
- generation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- cellular membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Gp1bb gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of platelet activation
- megakaryocyte development
- blood coagulation, intrinsic pathway
- cell adhesion
- cell surface receptor signaling pathway
- release of sequestered calcium ion into cytosol
- platelet activation
Cellular Component
Where in the cell the gene product is active
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- transmembrane signaling receptor activity