Upk1a Gene Summary [Mouse]
Predicted to be involved in epithelial cell differentiation. Located in apical plasma membrane. Is active in apical plasma membrane urothelial plaque. Is expressed in heart ventricle; lower urinary tract; lung; and rectum. Orthologous to human UPK1A (uroplakin 1A). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Upk1a |
| Official Name | uroplakin 1A [Source:MGI Symbol;Acc:MGI:98911] |
| Ensembl ID | ENSMUSG00000006313 |
| Bio databases IDs | |
| Aliases | uroplakin 1A |
| Synonyms | 1110031P12Rik, C87192, TSPAN21, UP1A, UPIA, Upk1, UPKA, uroplakin 1A |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Upk1a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- tetraspanin_LEL
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- cellular membrane
- Endoplasmic Reticulum
- apical membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Upk1a gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- epithelial cell differentiation
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- membrane
- macromolecular complex
- endoplasmic reticulum
- plasma membrane
- cell surface
Molecular Function
What the gene product does at the molecular level
- protein binding