Tgfb1i1 Gene Summary [Mouse]
Predicted to enable several functions, including I-SMAD binding activity; Roundabout binding activity; and nuclear androgen receptor binding activity. Acts upstream of or within several processes, including epithelial cell differentiation; morphogenesis of embryonic epithelium; and negative regulation of fat cell differentiation. Located in focal adhesion. Is expressed in several structures, including bronchus; central nervous system; genitourinary system; heart; and vertebral axis musculature. Orthologous to human TGFB1I1 (transforming growth factor beta 1 induced transcript 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tgfb1i1 |
| Official Name | transforming growth factor beta 1 induced transcript 1 [Source:MGI Symbol;Acc:MGI:102784] |
| Ensembl ID | ENSMUSG00000030782 |
| Bio databases IDs | |
| Aliases | transforming growth factor beta 1 induced transcript 1 |
| Synonyms | ARA55, HIC-5, TGF beta 1I1, TGF β 1I1, transforming growth factor beta 1 induced transcript 1, transforming growth factor β 1 induced transcript 1, TSC-5 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Tgfb1i1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SMAD binding
- transcription regulator
- leucine rich domain
- transcription co-activator
- fxxlf motif
- LIM is a small protein-protein interaction domain, containing two zinc fingers
- androgen receptor binding
- protein binding
- receptor binding
- PXsP motif
- RXXsL motif
- zinc finger domain
- paxillin LD motif
- Serine Proline motif
Pathways
Biological processes and signaling networks where the Tgfb1i1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- preeclampsia
- familial obesity
- keratocystic odontogenic tumor
- keratocystic odontogenic tumors
- endometrial cancer
- uterine serous papillary cancer
- primary central nervous system lymphoma
- primary cancer
- lymphomagenesis
- central nervous system cancer
role in cell
- cell death
- apoptosis
- growth
- expression in
- activation in
- phosphorylation in
- migration
- proliferation
- cell spreading
- differentiation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- intracellular membrane-bounded organelle
- Cytoplasm
- cell periphery
- focal adhesions
- cytoplasmic aggregates
- cytosol
- plasma membrane projections
- nuclear matrix
- neurites
- synapse
- membrane processes
- perikaryon
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Tgfb1i1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
- negative regulation of cell proliferation
- negative regulation of fat cell differentiation
- cell adhesion
- fat cell differentiation
- epithelial cell differentiation
- positive regulation of epithelial to mesenchymal transition
- positive regulation of transcription, DNA-dependent
- cell fate commitment
- Wnt receptor signaling pathway
- morphogenesis of embryonic epithelium
- positive regulation of transforming growth factor beta receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- cytoskeleton
- focal adhesion
- intracellular membrane-bounded organelle
- nuclear matrix
- cytosol
Molecular Function
What the gene product does at the molecular level
- Roundabout binding
- protein binding
- transcription coactivator activity
- androgen receptor binding
- metal ion binding
- I-SMAD binding