Gp1ba Gene Summary [Mouse]
Involved in blood coagulation and megakaryocyte development. Acts upstream of or within cell morphogenesis and hemostasis. Located in cell surface. Colocalizes with external side of plasma membrane. Is expressed in dorsal root ganglion; embryo; liver; and spinal cord. Used to study Bernard-Soulier syndrome. Human ortholog(s) of this gene implicated in Bernard-Soulier syndrome; Bernard-Soulier syndrome type A2; myocardial infarction; non-arteritic anterior ischemic optic neuropathy; and platelet-type bleeding disorder 3. Orthologous to human GP1BA (glycoprotein Ib platelet subunit alpha). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Gp1ba |
| Official Name | glycoprotein 1b, alpha polypeptide [Source:MGI Symbol;Acc:MGI:1333744] |
| Ensembl ID | ENSMUSG00000050675 |
| Bio databases IDs | |
| Aliases | glycoprotein 1b, alpha polypeptide |
| Synonyms | BDPLT1, BDPLT3, BSS, CD42B, CD42b-alpha, CD42b-α, DBPLT3, glycoprotein 1b, alpha polypeptide, Glycoprotein 1b α, glycoprotein 1b, α polypeptide, glycoprotein Ib platelet subunit alpha, glycoprotein Ib platelet subunit α, GP1B, GP1B alpha, GP1B α, GPIbA, GP-Ib alpha, GP-Ib α, LOC687719, VWDP |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Gp1ba often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- 14-3-3 binding domain
- extracellular domain
- filamin binding domain
- protein phosphatase 1 regulatory subunit 42
- ectodomain
- Leucine rich repeat
- Leucine rich repeat C-terminal domain
- protein binding
- Leucine Rich repeats (2 copies)
- leucine-rich repeat
- Cornifin (SPRR) family
- cytoplasmic domain
- intracellular domain
- Leucine rich repeat N-terminal domain
- cytosolic tail domain
- Metaviral_G glycoprotein
- transmembrane receptor
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- bleeding
- rheumatoid arthritis
- colorectal cancer
- Bernard-Soulier syndrome
- Bernard-Soulier syndrome type A1
- Bernard-Soulier syndrome type A2
- platelet type pseudo-von Willebrand disease
- primary antiphospholipid antibody syndrome
- thrombocytopenia
- essential thrombocythemia
role in cell
- expression in
- recruitment
- quantity
- formation in
- binding in
- formation
- binding
- adhesion
- activation
- aggregation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- cellular membrane
- plasma membrane extracellular face
- plasma
- actin cytoskeletal fractions
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Gp1ba gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of platelet activation
- regulation of blood coagulation
- cell morphogenesis
- blood coagulation, intrinsic pathway
- cell surface receptor signaling pathway
- cell adhesion
- blood coagulation
- fibrinolysis
- thrombin receptor signaling pathway
- megakaryocyte development
- release of sequestered calcium ion into cytosol
- platelet activation
Cellular Component
Where in the cell the gene product is active
- extracellular space
- extracellular vesicular exosome
- membrane
- external side of plasma membrane
- extracellular matrix
- plasma membrane
- cell surface
Molecular Function
What the gene product does at the molecular level
- protein binding
- thrombin receptor activity