Vwc2 Gene Summary [Mouse]
Involved in negative regulation of BMP signaling pathway; neurotransmitter receptor localization to postsynaptic specialization membrane; and positive regulation of neuron differentiation. Acts upstream of or within positive regulation of cell-substrate adhesion. Located in basement membrane; extracellular space; and interstitial matrix. Part of AMPA glutamate receptor complex. Is active in glutamatergic synapse. Is extrinsic component of postsynaptic membrane. Is expressed in several structures, including alimentary system; cardiovascular system; hemolymphoid system gland; liver; and nervous system. Orthologous to human VWC2 (von Willebrand factor C domain containing 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Vwc2 |
| Official Name | von Willebrand factor C domain containing 2 [Source:MGI Symbol;Acc:MGI:2442987] |
| Ensembl ID | ENSMUSG00000050830 |
| Bio databases IDs | |
| Aliases | von Willebrand factor C domain containing 2 |
| Synonyms | A930041G11Rik, Brorin, cradin, G11, PSST739, UNQ739, von Willebrand factor C domain containing 2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Vwc2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- von Willebrand factor type C domain
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- glutaminergic synapse
- Plasma Membrane
- extracellular matrix
- basement membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Vwc2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of BMP signaling pathway
- positive regulation of neuron differentiation
- positive regulation of cell-substrate adhesion
Cellular Component
Where in the cell the gene product is active
- alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex
- extracellular space
- basement membrane
- interstitial matrix
- synapse
Molecular Function
What the gene product does at the molecular level
- protein binding