Get3

Predicted to enable ATP hydrolysis activity and membrane insertase activity. Predicted to be involved in tail-anchored membrane protein insertion into ER membrane. Predicted to act upstream of or within post-translational protein targeting to endoplasmic reticulum membrane. Predicted to be located in nucleolus and nucleoplasm. Predicted to be part of GET complex. Predicted to be active in endoplasmic reticulum membrane. Is expressed in several structures, including central nervous system; foregut; ganglia; respiratory system; and tooth. Human ortholog(s) of this gene implicated in dilated cardiomyopathy. Orthologous to human GET3 (guided entry of tail-anchored proteins factor 3, ATPase). [provided by Alliance of Genome Resources, Apr 2025]

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Get3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.

Describes the biological processes, cellular components, and molecular functions associated with the mouse Get3 gene, providing context for its role in the cell.