Fbxw5 Gene Summary [Mouse]
Predicted to enable protein kinase binding activity. Involved in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; protein ubiquitination; and regulation of mitotic nuclear division. Part of SCF ubiquitin ligase complex. Is expressed in central nervous system; embryo; retina inner nuclear layer; and retina outer nuclear layer. Orthologous to human FBXW5 (F-box and WD repeat domain containing 5). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Fbxw5 |
| Official Name | F-box and WD-40 domain protein 5 [Source:MGI Symbol;Acc:MGI:1354731] |
| Ensembl ID | ENSMUSG00000015095 |
| Bio databases IDs | |
| Aliases | F-box and WD-40 domain protein 5 |
| Synonyms | F-box and WD-40 domain protein 5, F-box and WD repeat domain containing 5, Fbw5 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Fbxw5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- F-box domain
- protein kinase binding
- WD40 repeats
- F-box domain superfamily
- F-box-like
- WD domain, G-beta repeat
- WD40
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
role in cell
- phosphorylation in
- ubiquitination in
- degradation in
- duplication
- homologous recombination in
- serine phosphorylation in
- threonine phosphorylation in
- formation
- overduplication in
- overduplication
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Fbxw5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- proteasomal ubiquitin-dependent protein catabolic process
- regulation of centrosome duplication
- regulation of mitosis
- SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
- protein ubiquitination
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- cytosol
- SCF ubiquitin ligase complex
- CUL4 RING ubiquitin ligase complex
Molecular Function
What the gene product does at the molecular level
- protein kinase binding
- protein binding