Sgms2 Gene Summary [Mouse]
Sphingomyelin, a major component of cell and Golgi membranes, is made by the transfer of phosphocholine from phosphatidylcholine onto ceramide, with diacylglycerol as a side product. The protein encoded by this gene is an enzyme that catalyzes this reaction primarily at the cell membrane. The synthesis is reversible, and this enzyme can catalyze the reaction in either direction. The encoded protein is required for cell growth. [provided by RefSeq, Oct 2008]
Details
| Type | Protein Coding |
| Official Symbol | Sgms2 |
| Official Name | sphingomyelin synthase 2 [Source:MGI Symbol;Acc:MGI:1921692] |
| Ensembl ID | ENSMUSG00000050931 |
| Bio databases IDs | |
| Aliases | sphingomyelin synthase 2 |
| Synonyms | 4933405A16RIK, 5133401H06Rik, AC165416.3, CDL, LOC102724049, MGC26963, RGD1305778, SMS2, spermatin, sphingomyelin synthase 2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Sgms2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- substituted phosphate group transferase
- ceramide cholinephosphotransferase
- PAP2 superfamily C-terminal
- enzyme
- protein binding
- sphingomyelin synthase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- obesity
- organismal death
- septic shock
- calvarial doughnut lesions with bone fragility and spondylometaphyseal dysplasia
- hereditary disorder
- COVID-19
- dermatitis
- hemolysis
- calvarial doughnut lesions with bone fragility
role in cell
- expression in
- quantity
- apoptosis
- accumulation in
- activation in
- phosphorylation in
- production in
- synthesis in
- cellular infiltration by
- release
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Golgi Apparatus
- endoplasmic reticulum membrane
- Golgi membrane
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Sgms2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- ceramide biosynthetic process
- sphingomyelin biosynthetic process
- sphingolipid biosynthetic process
- regulation of bone mineralization
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- Golgi apparatus
- Golgi membrane
- plasma membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ceramide cholinephosphotransferase activity
- protein binding
- sphingomyelin synthase activity
- kinase activity