Akap5 Gene Summary [Mouse]
Enables adenylate cyclase binding activity and molecular adaptor activity. Involved in several processes, including neuronal ion channel clustering; postsynaptic neurotransmitter receptor cycle; and synapse assembly. Acts upstream of or within several processes, including amylase secretion; cellular response to calcium ion; and cellular response to xenobiotic stimulus. Located in cytoskeleton; dendrite; and plasma membrane. Is active in postsynaptic recycling endosome. Is expressed in brain. Orthologous to human AKAP5 (A-kinase anchoring protein 5). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Akap5 |
| Official Name | A kinase (PRKA) anchor protein 5 [Source:MGI Symbol;Acc:MGI:2685104] |
| Ensembl ID | ENSMUSG00000021057 |
| Bio databases IDs | |
| Aliases | A kinase (PRKA) anchor protein 5 |
| Synonyms | 3526401B18RIK, AKAP 150, AKAP75, AKAP79, AKAP79/150, A-kinase anchoring protein 5, A kinase anchor protein 5, Gm258, H21, P150 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Akap5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Pka rii anchoring domain
- G-protein-coupled receptor binding
- calcineurin-inhibitory domain
- Calcineurin a binding domain
- MAGUK recruitment domain
- actin binding
- cadherin binding
- basic domain
- phosphatidylinositol 4,5-biphosphate binding domain
- protein kinase A binding
- protein kinase binding
- calmodulin binding
- calmodulin binding domain
- WSK motif
- Pkc binding domain
- protein domain specific binding
- calcineurin-binding domain
- protein binding
- receptor binding
- SH3-domain binding
- polybasic membrane localization signal
- kinase binding
- binding protein
- PKA binding domain
- adenylate cyclase binding
- protein phosphatase 2B binding
Pathways
Biological processes and signaling networks where the Akap5 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hyperalgesia
- Waldenström macroglobulinemia
- Alzheimer disease
- seizures
- soft tissue sarcoma cancer
- soft tissue sarcoma
role in cell
- binding in
- expression in
- quantity
- production in
- phosphorylation in
- transport in
- assembly
- differentiation
- hypertrophy
- inhibition in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- membrane fraction
- glutaminergic synapse
- cytoskeleton
- organelle
- Cytoplasm
- cell periphery
- somatodendritic region
- perinuclear region
- postsynaptic region
- cellular membrane
- endosomes
- cytosol
- cytoplasmic face of plasma membrane
- membrane ruffles
- basolateral membrane
- lateral plasma membrane
- dendritic spines
- neurites
- dendritic trees
- synaptosomes
- synapse
- recycling endosomes
- anchoring junction
- membrane rafts
- filopodia
- postsynaptic spines
- perikaryon
- dendrites
- excitatory synapses
- dendritic shafts
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Akap5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- calcineurin-NFAT signaling cascade
- adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
- negative regulation of adenylate cyclase activity
- signal transduction
- positive regulation of long-term synaptic potentiation
- regulation of protein kinase A signaling cascade
- synaptic transmission
- positive regulation of calcineurin-NFAT signaling cascade
Cellular Component
Where in the cell the gene product is active
- postsynaptic density
- dendrite membrane
- protein serine/threonine phosphatase complex
- dendritic spine
- membrane raft
- excitatory synapse
- cytosol
- plasma membrane
- internal side of plasma membrane
Molecular Function
What the gene product does at the molecular level
- glutamate receptor binding
- adenylate cyclase binding
- scaffold protein binding
- calmodulin binding
- protein binding
- protein kinase A regulatory subunit binding
- SH3 domain binding
- GABA receptor binding
- protein kinase A binding
- protein phosphatase 2B binding
- binding, bridging
- beta-2 adrenergic receptor binding