Tmpo Gene Summary [Mouse]
Enables identical protein binding activity. Acts upstream of or within regulation of DNA-templated transcription. Located in nuclear envelope. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and sensory organ. Orthologous to human TMPO (thymopoietin). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tmpo |
| Official Name | thymopoietin [Source:MGI Symbol;Acc:MGI:106920] |
| Ensembl ID | ENSMUSG00000019961 |
| Bio databases IDs | |
| Aliases | thymopoietin |
| Synonyms | 5630400D24Rik, AW547477, CMD1T, LAP2, LEMD4, PRO0868, thymopoietin, TP, TP alpha, TP beta/gamma, TP α, TP β/γ |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Tmpo often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Lamina-associated polypeptide 2 alpha
- DNA binding domain
- nucleoplasmic domain
- LEM-like domain of lamina-associated polypeptide 2 (LAP2) and similar proteins
- replication initiation involved domain
- nuclear localization sequence
- lamin binding
- HA95 binding domain
- protein binding
- identical protein binding
- germ cell less binding domain
- transmembrane domain
- chromatin binding domain
- lamin-B binding domain
- lamin binding domain
- BAF binding domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- familial isolated dilated cardiomyopathy
- Hutchinson-Gilford progeria syndrome
- small cell lung cancer
- hypertrophic cardiomyopathy
- gastric cancer
role in cell
- expression in
- differentiation
- cell cycle progression
- number
- proliferation
- invasion
- migration
- accumulation in
- formation
- formation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- interchromatin granule cluster fractions
- nuclear fraction
- soluble fraction
- nuclear membrane fraction
- pH resistant lipid raft fraction
- detergent resistant lipid raft fraction
- Cytoplasm
- Mitochondria
- nuclear pores
- inner nuclear membrane
- nucleoplasm
- nuclear rim
- nuclear envelope
- chromatin
- detergent-soluble fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Tmpo gene, providing context for its role in the cell.
Cellular Component
Where in the cell the gene product is active
- nuclear envelope
- nucleus
- nuclear inner membrane
- nuclear membrane
- cytoplasm
- membrane
- chromatin
Molecular Function
What the gene product does at the molecular level
- DNA binding
- protein binding
- cadherin binding
- lamin binding