Tmem199

Enables oxysterol binding activity. Predicted to be involved in cellular response to increased oxygen levels; intracellular monoatomic cation homeostasis; and lysosomal protein catabolic process. Predicted to be located in COPI-coated vesicle membrane; endoplasmic reticulum; and endoplasmic reticulum-Golgi intermediate compartment membrane. Predicted to be part of vacuolar proton-transporting V-type ATPase complex. Predicted to be active in endomembrane system. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation type IIp. Orthologous to human TMEM199 (transmembrane protein 199). [provided by Alliance of Genome Resources, Jul 2025]

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Tmem199 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.

Describes the biological processes, cellular components, and molecular functions associated with the mouse Tmem199 gene, providing context for its role in the cell.