Tmed2 Gene Summary [Mouse]
Enables frizzled binding activity and smoothened binding activity. Involved in embryonic morphogenesis; labyrinthine layer blood vessel development; and maternal placenta development. Acts upstream of or within several processes, including chordate embryonic development; regulation of gene expression; and regulation of signal transduction. Located in Golgi apparatus; endoplasmic reticulum membrane; and endoplasmic reticulum-Golgi intermediate compartment. Is expressed in several structures, including cardiovascular system; early conceptus; embryo ectoderm; placenta; and trunk mesenchyme. Orthologous to human TMED2 (transmembrane p24 trafficking protein 2). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tmed2 |
| Official Name | transmembrane p24 trafficking protein 2 [Source:MGI Symbol;Acc:MGI:1929269] |
| Ensembl ID | ENSMUSG00000029390 |
| Bio databases IDs | |
| Aliases | transmembrane p24 trafficking protein 2 |
| Synonyms | 1110032D12Rik, 1810020N21Rik, Intracellular protein transport, p24, P24A, p24b1, p24beta1, RNP24, Sid394, transmembrane p24 trafficking protein 2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Tmed2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- frizzled binding
- smoothened binding
- protein binding
- emp24/gp25L/p24 family/GOLD
- sorting signal domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neonatal late-onset sepsis
- gastric adenocarcinoma
- gastric epithelial cancer
- infection by HIV-1
role in cell
- growth
- organization
- cargo loading in
- trafficking in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- pH resistant lipid raft fraction
- intracellular membrane-bounded organelle
- cellular membrane
- vesicles
- Golgi Apparatus
- Endoplasmic Reticulum
- ER-to-Golgi intermediate compartment
- endoplasmic reticulum membrane
- Golgi membrane
- zymogen granules
- transport vesicles
- microsomal membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Tmed2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- multicellular organism growth
- negative regulation of GTPase activity
- endoplasmic reticulum membrane organization
- Golgi organization
- branching involved in labyrinthine layer morphogenesis
- COPI coating of Golgi vesicle
- intracellular protein transport
- negative regulation of smoothened signaling pathway
- protein secretion
- maternal placenta development
- COPII vesicle coating
- ER to Golgi vesicle-mediated transport
- inflammatory response
- labyrinthine layer blood vessel development
- neural tube closure
- chorion development
- positive regulation of gene expression
- maintenance of protein localization to organelle
- regulation of SREBP-mediated signaling pathway
- cargo loading into vesicle
- heart looping
- somite rostral/caudal axis specification
- protein localization in plasma membrane
Cellular Component
Where in the cell the gene product is active
- Golgi cisterna membrane
- Golgi apparatus
- Golgi membrane
- endoplasmic reticulum
- endoplasmic reticulum-Golgi intermediate compartment
- zymogen granule membrane
- endoplasmic reticulum membrane
- intracellular membrane-bounded organelle
- ER to Golgi transport vesicle membrane
- membrane
- ER to Golgi transport vesicle
- transport vesicle
- COPI coated vesicle membrane
- endoplasmic reticulum-Golgi intermediate compartment membrane
- COPI-coated vesicle
Molecular Function
What the gene product does at the molecular level
- frizzled binding
- protein binding
- smoothened binding
- cargo receptor activity