Dnajc1 Gene Summary [Mouse]
Enables protein-folding chaperone binding activity. Acts upstream of or within protein folding and regulation of translation. Located in endoplasmic reticulum and plasma membrane. Orthologous to human DNAJC1 (DnaJ heat shock protein family (Hsp40) member C1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Dnajc1 |
| Official Name | DnaJ heat shock protein family (Hsp40) member C1 [Source:MGI Symbol;Acc:MGI:103268] |
| Ensembl ID | ENSMUSG00000026740 |
| Bio databases IDs | |
| Aliases | DnaJ heat shock protein family (Hsp40) member C1 |
| Synonyms | 4733401K02RIK, D230036H06RIK, DnaJ heat shock protein family (Hsp40) member C1, DNAJL1, ERdj1, ERj1p, HTJ1, LOC100504126, MTJ1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Dnajc1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- DnaJ domain
- ATPase stimulator
- SANT
- DnaJ
- SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
- DnaJ molecular chaperone homology domain
- Myb-like DNA-binding domain
- ribosome binding
- protein binding
- chaperone binding
Pathways
Biological processes and signaling networks where the Dnajc1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- acute myeloid leukemia
- liver cancer
- epithelial cancer
- hepatocellular carcinoma
- organismal death
- acute lung injury
- insomnia
- breast carcinoma
- endometriosis
- essential hypertension
role in cell
- expression in
- proliferation
- migration
- apoptosis
- invasion by
- translation in
- binding
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cellular membrane
- Nucleus
- Plasma Membrane
- Endoplasmic Reticulum
- endoplasmic reticulum lumen
- microsome
- microsomal membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Dnajc1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of translation
- regulation of protein secretion
- negative regulation of proteolysis
- protein folding
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- nuclear membrane
- membrane
- endomembrane system
- endoplasmic reticulum
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- DNA binding
- protein binding
- chaperone binding
- ATPase activator activity