Slc39a1 Gene Summary [Mouse]
Enables zinc ion transmembrane transporter activity. Acts upstream of or within chordate embryonic development; limb development; and zinc ion transport. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Orthologous to human SLC39A1 (solute carrier family 39 member 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Slc39a1 |
| Official Name | solute carrier family 39 (zinc transporter), member 1 [Source:MGI Symbol;Acc:MGI:1353474] |
| Ensembl ID | ENSMUSG00000052310 |
| Bio databases IDs | |
| Aliases | solute carrier family 39 (zinc transporter), member 1 |
| Synonyms | solute carrier family 39 member 1, solute carrier family 39 (zinc transporter), member 1, ZIP1, ZIRTL |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Slc39a1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ZIP Zinc transporter
- inorganic uptake permease
- protein binding
- receptor binding
- zinc ion transporter
- transporter
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- prostatic adenocarcinoma
- prostate cancer
- pervasive developmental disorder
- prostatic carcinoma
regulates
- Zn2+
- heavy metal
- cation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- perinuclear region
- cellular membrane
- granules
- endoplasmic reticulum membrane
- perikaryon
- axons
- dendrites
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Slc39a1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cation transport
- in utero embryonic development
- limb development
- embryonic cranial skeleton morphogenesis
- zinc ion transmembrane transport
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- inorganic cation transmembrane transporter activity
- protein binding
- zinc ion transmembrane transporter activity
- receptor binding