P2ry12 Gene Summary [Mouse]
Enables G protein-coupled ADP receptor activity and G protein-coupled adenosine receptor activity. Involved in several processes, including cellular response to ATP; regulation of microglial cell migration; and substrate-dependent cell migration, cell extension. Acts upstream of or within adenylate cyclase-modulating G protein-coupled receptor signaling pathway; platelet activation; and positive regulation of monoatomic ion transport. Located in cell body membrane and cell projection membrane. Is expressed in central nervous system and cerebral cortex. Used to study platelet-type bleeding disorder 8. Human ortholog(s) of this gene implicated in asthma; cerebrovascular disease; peripheral artery disease; platelet-type bleeding disorder 8; and type 2 diabetes mellitus. Orthologous to human P2RY12 (purinergic receptor P2Y12). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | P2ry12 |
| Official Name | purinergic receptor P2Y, G-protein coupled 12 [Source:MGI Symbol;Acc:MGI:1918089] |
| Ensembl ID | ENSMUSG00000036353 |
| Bio databases IDs | |
| Aliases | purinergic receptor P2Y, G-protein coupled 12 |
| Synonyms | 2900079B22Rik, 4921504D23Rik, ADPG-R, BDPLT8, HORK3, P2TAC, P2T(AC), P2Y12, P2Y(12)R, P2Y12 receptor, P2Y(AC), P2Y(ADP), P2Y(cyc), purinergic receptor P2Y12, purinergic receptor P2Y, G-protein coupled 12, SP1999 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse P2ry12 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- Cholecystokinin A receptor, N-terminal
- G-protein coupled adenosine receptor
- guanyl-nucleotide exchange factor
- transmembrane domain
- 7 transmembrane receptor (rhodopsin family)
- cytosolic tail domain
- platelet ADP receptor
- seven-transmembrane G protein-coupled receptor superfamily
Pathways
Biological processes and signaling networks where the P2ry12 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- heart failure
- chronic kidney disease
- atrial fibrillation
- non-insulin-dependent diabetes mellitus
- renal failure
- disorder of coronary artery
- acute coronary syndrome
- unstable angina
- hypertension
role in cell
- quantity
- production in
- cellular infiltration by
- migration
- expression in
- activation in
- binding
- adhesion
- aggregation
- inhibition in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- intracellular compartment
- cell surface
- intracellular space
- cellular membrane
- plasma membrane extracellular face
- caveolae
- basal membrane
- cellular protrusions
- perikaryon
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse P2ry12 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
- cell projection organization
- response to axon injury
- hemostasis
- ion transport
- positive regulation of ion transport
- positive regulation of cell adhesion mediated by integrin
- establishment of localization in cell
- cellular response to ATP
- calcium-mediated signaling
- platelet activation
- platelet aggregation
- G-protein coupled receptor signaling pathway
- cerebral cortex radial glia guided migration
- phospholipase C-activating G-protein coupled receptor signaling pathway
- substrate-dependent cell migration, cell extension
- positive regulation of ruffle assembly
- adenosine receptor signaling pathway
- positive regulation of integrin activation by cell surface receptor linked signal transduction
- lamellipodium assembly
- regulation of chemotaxis
- positive regulation of chemotaxis
- positive regulation of protein kinase B signaling cascade
- G-protein coupled purinergic nucleotide receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- cell body membrane
- membrane
- cell projection membrane
- plasma membrane
- cell surface
Molecular Function
What the gene product does at the molecular level
- ADP receptor activity
- guanyl-nucleotide exchange factor activity
- G-protein coupled purinergic nucleotide receptor activity
- G-protein coupled adenosine receptor activity